New Secondary Metabolites from an Endophytic Fungus in Porodaedalea pini

被引：0
|
作者：
Yang, Shuen-Shin [1 ]
Cheng, Ming-Jen [2 ]
Chan, Hing-Yuen [2 ]
Hsieh, Sung-Yuan [2 ]
Wu, Ho-Cheng [1 ]
Yuan, Gwo-Fang [2 ]
Lin, Chu-Hung [3 ]
Chang, Hsun-Shuo [1 ,3 ,4 ,5 ]
Chen, Ih-Sheng [1 ,3 ,4 ]
机构：
[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807, Taiwan
[2] FIRDI, BCRC, Hsinchu 300, Taiwan
[3] Kaohsiung Med Univ, Sch Pharm, Coll Pharm, Kaohsiung 807, Taiwan
[4] Kaohsiung Med Univ, Res Ctr Nat Prod & Drug Dev, Kaohsiung 807, Taiwan
[5] Kaohsiung Med Univ, Ctr Infect Dis & Canc Res CICAR, Kaohsiung 807, Taiwan
来源：
RECORDS OF NATURAL PRODUCTS | 2017年 / 11卷 / 03期
关键词：
Porodaedalea pini; fungus; benzenoids; NO inhibitory activity; androgen antagonism; TUMOR-CELL-LINES; CONSTITUENTS; EPOXIDES; ASSAY;
D O I：
暂无
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Eight benzenoids including three new phenols, piniphenols A-C (1-3), along with five known compounds, 4-vinylphenol (4) and 4-hydroxybenzaldehyde (5), 2-methoxy-2-(4'-hydroxyphenyl) ethanol (6), 2,3-dihydroxypropyl acetate (7), and phenol (8) were isolated from ethyl acetate layer of liquid fermentation with Porodaedalea pini (Hymenochaetaceae) BCRC 35384. All structures were established by spectral analysis and comparison with the literature data. Of these isolates, 1 showed moderate NO inhibitory activity with an IC50 value of 60.0 mu M. Compound 1 also showed the androgen receptor (AR) antagonism with the IC50 value of 0.42 mu M. To the best of our knowledge, this is the first report on benzenoid metabolites from the genus Porodaedalea.
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页码：251 / 257
页数：7
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