Purpose Firms must be constantly looking for markets and business opportunities and developing new products; to do so, they must find ways to increase their competitiveness, productivity so that it is noticed in their financial statements. The purpose of this paper is to establish the influence of entrepreneurial orientation (EO) in business performance (BP) of small and medium-sized enterprises of the manufacturing sector in Mexico. Likewise, it is intended to demonstrate how absorptive capacity (ACAP) allows moderating this important relation. Design/methodology/approach Analyzing important theoretical and empirical contributions as regards this topic, a survey was designed and applied to 165 manufacturing firms, and by means of partial least squares structural equation modeling resorting to SmartPLS, the research hypotheses were tried. Findings The obtained results indicate that indeed, EO positively influences BP; in like manner, ACAP has a moderating effect on this relation. Thereby, it can be established that the manufacturing sector carries out the right practices that aim at increasing entrepreneurial competitiveness. Originality/value This paper contributes to broadening the studies on EO, ACAP and BP in a different context. Besides, it allows contrasting the results obtained in an eminently manufacturing country with other economies less dependent on this sector. It also contributes to broadening the multidimensional analysis of the manufacturing sector in Mexico, as the authors of the present paper have also performed studies over similar lines in the same sector.