Benzopyran sulfonamides as Kv1.5 potassium channel blockers

被引：29
|
作者：
Lloyd, John [1 ]
Atwal, Karnail S. [1 ]
Finlay, Heather J. [1 ]
Nyman, Michael [1 ]
Huynh, Tram [1 ]
Bhandaru, Rao [1 ]
Kover, Alexander [1 ]
Schmidt, Joan [1 ]
Vaccaro, Wayne [1 ]
Conder, Mary Lee [1 ]
Jenkins-West, Tonya [1 ]
Levesque, Paul [1 ]
机构：
[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Princeton, NJ 08543 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 12期
关键词：
K(v)1.5; I-Kur; ultra rapid potassium current; potassium ion channel; ion channel blocker; antiarrhythmic; atrial arrhythmia; atrial fibrillation;
D O I：
10.1016/j.bmcl.2007.04.020
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
K-v 1.5 blockers have the potential to be atrium-selective agents for treatment of atrial fibrillation. The benzopyrans provide a template for the synthesis of potent and selective K-v 1.5 blockers. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3271 / 3275
页数：5
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