'Green' synthesis of 1,4-disubstituted 5-iodo-1,2,3-triazoles under neat conditions, and an efficient approach of construction of 1,4,5-trisubstituted 1,2,3-triazoles in one pot

被引：20
|
作者：
Wang, Dong
Chen, Si
Chen, Baohua [1 ]
机构：
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 51期
基金：
美国国家科学基金会;
关键词：
Solvent-free; 5-Iodo-1,2,3-triazoles; One-pot synthesis; 1,4,5-Trisubstituted 1,2,3-triazoles; CLICK-CHEMISTRY; CATALYZED CYCLOADDITION; CASCADE REACTIONS; ORGANIC AZIDES; ALKYNES; ARYLATION; LIGATION; SURFACES;
D O I：
10.1016/j.tetlet.2014.10.128
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An environmentally friendly and efficient method for synthesis of 1,4-disubstituted 5-iodo-1,2,3-triazoles through [Cu(phen)(PPh3)(2)]NO3-catalyzed cycloaddition of organic azides and iodoalkynes under solvent-free conditions was developed. Based on this, a one-pot method for the synthesis of fully substituted 1,2,3-triazoles via cycloaddition/Suzuki reactions was also demonstrated in this report. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7026 / 7028
页数：3
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