The DNA methylation inhibitor 5-aza-2′-deoxycytidine (5-azadC) induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases (DNMTs) 1 and 3B

被引:0
|
作者
Robertson, Keith D. [1 ]
Sankpal, Umesh [1 ]
Brown, Kevin D. [1 ]
机构
[1] Univ Florida, Gainesville, FL 32610 USA
来源
FASEB JOURNAL | 2007年 / 21卷 / 05期
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:A660 / A660
页数:1
相关论文
共 50 条
  • [41] DNA methylation of retinoic acid receptor β in breast cancer and possible therapeutic role of 5-aza-2′-deoxycytidine
    Bovenzi, V
    Lê, NLO
    Cóté, S
    Sinnett, D
    Momparler, LF
    Momparler, RL
    ANTI-CANCER DRUGS, 1999, 10 (05) : 471 - 476
  • [42] Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2′-deoxycytidine
    Chuang, JC
    Yoo, CB
    Kwan, JM
    Li, TWH
    Liang, GN
    Yang, AS
    Jones, PA
    MOLECULAR CANCER THERAPEUTICS, 2005, 4 (10) : 1515 - 1520
  • [43] Inhibition of DNA methylation by 5-aza-2′-deoxycytidine correlates with induction of K562 cells differentiation
    Fabianowska-Majewska, K
    Wyczechowska, D
    Czyz, M
    PURINE AND PYRIMIDINE METABOLISM IN MAN X, 2000, 486 : 343 - 347
  • [44] Enhancement of the Antileukemic Action of the Inhibitors of DNA and Histone Methylation: 5-Aza-2′-Deoxycytidine and 3-Deazaneplanocin-A by Vitamin C
    Momparler, Richard L.
    Cote, Sylvie
    Momparler, Louise F.
    EPIGENOMES, 2021, 5 (02)
  • [45] Induction by 5-aza-2'-deoxycytidine, an inhibitor of DNA methylation, of Le(y) antigen, apoptosis and differentiation in human lung cancer cells
    Saitoh, F
    Hiraishi, K
    Adachi, M
    Hozumi, M
    ANTICANCER RESEARCH, 1995, 15 (5B) : 2137 - 2143
  • [46] 5-aza-2′-deoxycytidine induces histone hyperacetylation of mouse centromeric heterochromatin by a mechanism independent of DNA demethylation
    Takebayashi, S
    Nakao, M
    Fujita, N
    Sado, T
    Tanaka, M
    Taguchi, H
    Okumura, K
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 288 (04) : 921 - 926
  • [47] 5-Aza-2′-deoxycytidine, a DNA methylation inhibitor, induces cytotoxicity, cell cycle dynamics and alters expression of DNA methyltransferase 1 and 3A in mouse hippocampus-derived neuronal HT22 cells
    Yang, Jing
    Tian, Xiaoli
    Yang, Jie
    Cui, Junhe
    Jiang, Shuyuan
    Shi, Rui
    Liu, You
    Liu, Xiaolei
    Xu, Wenqiang
    Xie, Wei
    Jia, Xiaoe
    Bade, Rengui
    Zhang, Tao
    Zhang, Ming
    Gong, Kerui
    Yan, Shaochun
    Yang, Zhanjun
    Shao, Guo
    JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 2017, 80 (22): : 1222 - 1229
  • [48] Inhibition of DNA methylation by continuous infusion of 5-Aza-2′-Deoxycytidine (Decitabine):: A phase I study with molecular goals
    Leachman, S
    Jones, D
    Karpf, A
    Florell, S
    Porter-Gill, P
    Wheeler, R
    Samlowsk, W
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2001, 117 (02) : 538 - 538
  • [49] Changes in the levels of DNA methylation in testis and liver of SD rats neonatally exposed to 5-aza-2′-deoxycytidine and cadmium
    Zhu, Hongyan
    Li, Keyong
    Liang, Jiren
    Zhang, Jie
    Wu, Qing
    JOURNAL OF APPLIED TOXICOLOGY, 2011, 31 (05) : 484 - 495
  • [50] Potential of 5-aza-2′-deoxycytidine (Decitabine) a potent inhibitor of DNA methylation for therapy of advanced non-small cell lung cancer
    Momparler, RL
    Ayoub, J
    LUNG CANCER, 2001, 34 : S111 - S115