Alterations in glycosylation as biomarkers for cancer detection

被引：354
|
作者：
Reis, Celso A. [1 ,2 ]
Osorio, Hugo [1 ]
Silva, Luisa [1 ]
Gomes, Catarina [1 ]
David, Leonor [1 ,2 ]
机构：
[1] Univ Porto, IPATIMUP, Inst Mol Pathol & Immunol, P-4200465 Oporto, Portugal
[2] Univ Porto, Fac Med, P-4100 Oporto, Portugal
来源：
JOURNAL OF CLINICAL PATHOLOGY | 2010年 / 63卷 / 04期
关键词：
POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE; ALPHA-D-GALACTOSAMINE; SIALYL-TN ANTIGEN; ACETYL-D-GALACTOSAMINE; ADENOCARCINOMA CELL-LINES; O-LINKED GLYCOSYLATION; PRIMARY BREAST-CANCER; HUMAN-COLON-CANCER; LEWIS-X ANTIGEN; GASTRIC-CANCER;
D O I：
10.1136/jcp.2009.071035
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Glycoconjugates constitute a major class of biomolecules which include glycoproteins, glycosphingolipids and proteoglycans. Glycans are involved in several physiological and pathological conditions, such as host-epathogen interactions, cell differentiation, migration, tumour invasion and metastisation, cell trafficking and signalling. Cancer is associated with glycosylation alterations in glycoproteins and glycolipids. This review describes various aspects of protein glycosylation with the focus on alterations associated with human cancer. The application of these glycosylation modifications as biomarkers for cancer detection in tumour tissues and serological assays is summarised.
引用
收藏
页码：322 / 329
页数：8
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