Suppressive effect of antibiotic siomycin on antibody production

被引：23

作者：

Ueno, M ^{[1
]}

Furukawa, S ^{[1
]}

Abe, F ^{[1
]}

Ushioda, M ^{[1
]}

Fujine, K ^{[1
]}

Johki, S ^{[1
]}

Hatori, H ^{[1
]}

Ueda, H ^{[1
]}

机构：

[1] Fujisawa Pharmaceut Co Ltd, Fermentat Res Labs, Tsukuba, Ibaraki 3002698, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2004年 / 57卷 / 09期

关键词：

D O I：

10.7164/antibiotics.57.590

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The antibiotic thiazole compound siomycin, which we have found from the culture broth of Actinomycetes (strain No.806097) in search of antibody production Inhibitor, showed the in vitro immunosuppressive property against B-cells stimulated with T-cell independent antigen DNP-LPS (dinitrophenyl-lipopolysaccharide) while it also showed inhibitory effect against T-cell proliferation. Its inhibitory mechanism was considered to be different from that of FK506, the representative of T-cell immunosuppressant. Moreover, siomycin showed inhibitory effect in both T-cell dependent and independent murine antibody production models and decreased the severity in murine collagen arthritis model. Therefore, siomycin is a unique immunosuppressant which has potential for the treatment of some anti body-mediated diseases.

引用

页码：590 / 596

页数：7

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