Telomere and Telomerase as Targets for Cancer Therapy

被引：44

作者：

Tian, Xiaoping ^{[1
]}

Chen, Bo ^{[1
]}

Liu, Xiaochuan ^{[1
]}

机构：

[1] Zhejiang Sci Tech Univ, Bioengn Inst, Life Sci Coll, Hangzhou 310018, Peoples R China

来源：

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | 2010年 / 160卷 / 05期

关键词：

Telomere; Telomerase; Telomere dysfunction; Telomerase RNA; Cancer therapy; HTERT MESSENGER-RNA; REVERSE-TRANSCRIPTASE EXPRESSION; TUMOR-ASSOCIATED ANTIGEN; CYTOTOXIC T-LYMPHOCYTES; SINGLE-STRAND OVERHANG; GROWTH IN-VITRO; SUICIDE GENE; STEM-CELLS; CELLULAR SENESCENCE; INHIBITION;

D O I：

10.1007/s12010-009-8633-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomere maintenance and telomerase reactivation is essential for the transformation of most human cancer cells. Telomere shortening to the threshold length, mutations of the telomere-associated proteins, and/or telomerase RNA lead to telomeric dysfunction and therefore genomic instability. Telomerase up-regulation in 85% of human cancer cells has become a hallmark of cancers, hence a promising target for anticancer therapy. In this review, we discuss the mechanism of cancer due to telomere dysfunction and the resulting biological effects, the control of telomerase activity, and the new developments in cancer therapies targeting telomere and telomerase.

引用

页码：1460 / 1472

页数：13

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