Hepatoprotective Effects of Insect Extracts in an Animal Model of Nonalcoholic Fatty Liver Disease

被引:28
|
作者
Im, A-Rang [1 ]
Yang, Won-Kyung [2 ]
Park, Yang-Chun [3 ]
Kim, Seung Hyung [2 ]
Chae, Sungwook [1 ,4 ]
机构
[1] Korea Inst Oriental Med, Herbal Med Res Div, 1672 Yuseong Daero, Daejeon 34053, South Korea
[2] Daejeon Univ, Inst Tradit Med & Biosci, 62 Daehak Ro, Daejeon 34520, South Korea
[3] Daejeon Univ, Coll Korean Med, Dept Internal Med, Div Resp Syst, 176 Daeduk Ro, Daejeon 35235, South Korea
[4] Univ Sci & Technol, Korean Med Life Sci, 217 Gajeong Ro, Daejeon 34113, South Korea
来源
NUTRIENTS | 2018年 / 10卷 / 06期
关键词
nonalcoholic fatty liver disease; edible insect; Protaetia brevitarsis seulensis; Oxya chinensis sinuosa; Gryllus bimaculatus; hepatoprotection; PROTAETIA-BREVITARSIS-SEULENSIS; METABOLIC SYNDROME; HOMEOSTASIS; FOOD;
D O I
10.3390/nu10060735
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Insects represent the largest and most diverse group of organisms on earth and are potential food and drug resources. Recently, we have demonstrated that a Forsythia viridissima extract prevented free fatty acid-induced lipid accumulation in an in vitro cellular nonalcoholic fatty liver disease (NAFLD) model. In this study, we aimed to evaluate the hepatoprotective effects of extracts of the insects Protaetia brevitarsis seulensis Kolbe, 1886 (PB), Oxya chinensis sinuosa Mishchenko, 1951 (OC), and Gryllus bimaculatus De Geer, 1773 (GB) in a high-fat diet (HFD)-induced NAFLD animal model, as well as to elucidate the underlying mechanisms. The effects of the supplementation with PB, OC, and GB extracts were evaluated histopathologically and histochemically. PB, OC, and GB extract supplementation inhibited the HFD-induced increase in body weight and body fat mass and ameliorated other adverse changes, resulting in decreased liver function parameters, lower serum triglyceride and cholesterol levels, and increased serum adiponectin levels. The expression of hepatic genes involved in lipid droplet accumulation and in fatty acid uptake also decreased upon treatment of HFD-fed mice with the extracts. These results provide evidence of the protective effects of the PB, OC, and GB extracts against HFD-induced fatty liver disease in an animal model.
引用
收藏
页数:19
相关论文
共 50 条
  • [41] Nonalcoholic fatty liver disease
    Elizabeth M. Brunt
    Vincent W.-S. Wong
    Valerio Nobili
    Christopher P. Day
    Silvia Sookoian
    Jacquelyn J. Maher
    Elisabetta Bugianesi
    Claude B. Sirlin
    Brent A. Neuschwander-Tetri
    Mary E. Rinella
    Nature Reviews Disease Primers, 1
  • [42] Nonalcoholic fatty liver disease
    Madan, P
    CANADIAN MEDICAL ASSOCIATION JOURNAL, 2005, 173 (07) : 734 - 735
  • [43] Nonalcoholic fatty liver disease
    Brunt, Elizabeth M.
    Wong, Vincent W. -S.
    Nobili, Valerio
    Day, Christopher P.
    Sookoian, Silvia
    Maher, Jacquelyn J.
    Bugianesi, Elisabetta
    Sirlin, Claude B.
    Neuschwander-Tetri, BrentA.
    Rinella, Mary E.
    NATURE REVIEWS DISEASE PRIMERS, 2015, 1
  • [44] Nonalcoholic Fatty Liver Disease
    Filipovic, Branka
    Forbes, Alastair
    Tepes, Bojan
    Dumitrascu, Dan L.
    CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2018, 2018
  • [45] Nonalcoholic fatty liver disease
    Bebawi, Emmanuel
    Takla, Mark
    Leonard, Jennifer
    CANADIAN MEDICAL ASSOCIATION JOURNAL, 2023, 195 (26) : E909 - E909
  • [46] Nonalcoholic fatty liver disease
    Lemoine, Maud
    Serfaty, Lawrence
    PRESSE MEDICALE, 2012, 41 (02): : 169 - 189
  • [47] Nonalcoholic Fatty Liver Disease
    Worm, N.
    Stein, J.
    Strohle, A.
    DIABETES STOFFWECHSEL UND HERZ, 2016, 25 (02): : 85 - 94
  • [48] Nonalcoholic fatty liver disease
    Mach, Tomasz
    PRZEGLAD GASTROENTEROLOGICZNY, 2007, 2 (02): : 101 - 105
  • [49] Nonalcoholic Fatty Liver Disease
    Isaacs, Scott
    ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2023, 52 (01) : 149 - 164
  • [50] Nonalcoholic Fatty Liver Disease
    Xia, Mao-Li
    Wang, Hai
    NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (03): : 294 - 295