Applying Liquid Chromatography (LC) and Liquid Chromatography Mass Spectrometry (LC-MS) Methods to the Characterization and Analysis of rAAV

被引：0

作者：

Koza, Stephan M. ^{[1
]}

Zhang, Ximo ^{[1
]}

Yang, Hua ^{[1
]}

Chen, Weibin ^{[2
]}

机构：

[1] Waters Corp, Milford, MA 01757 USA

[2] Waters Corp, Sci Operat, Milford, MA 01757 USA

来源：

LC GC EUROPE | 2020年 / 33卷 / 12期

关键词：

VECTORS; PARTICLES; GENOME;

D O I：

暂无

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Because of advances in the fundamental understanding of gene therapy treatments and the 2017 regulatory approval of a recombinant adeno-associated viral (rAAV) therapy, interest in developing rAAV-based therapies has increased. However, for patients worldwide to truly benefit from these therapies, significant improvements in the efficacy and manufacturing efficiency of rAAV are essential. We have recently seen substantial increases of inquiries regarding liquid chromatography (LC) and liquid chromatography-mass spectrometry (LC-MS) methods for the characterization and analysis of rAAV from scientists who are supporting advancements in product development.This edition of "Column Watch" highlights selected LC and LC-MS methods that can be applied to the analysis of these complex products.

引用

页码：607 / 613

页数：7

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