Inhibitory effect of polyozellin on secretory group IIA phospholipase A2

被引：3

作者：

Ku, Sae-Kwang ^{[1
]}

Yang, Eun-Ju ^{[2
]}

Kang, Hyejin ^{[1
]}

Jung, Byeongjin ^{[1
]}

Bae, Jong-Sup ^{[2
]}

机构：

[1] Daegu Hanny Univ, Coll Korean Med, Dept Anat & Histol, Gyongsan 712715, South Korea

[2] Kyungpook Natl Univ, Pharmaceut Sci Res Inst, CMRI, Coll Pharm, 80 Daehak Ro, Taegu 702701, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2016年 / 39卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Polyozellin; HUVECs; sPLA2-IIA; Inflammation; ARACHIDONIC-ACID RELEASE; NITRIC-OXIDE PRODUCTION; NF-KAPPA-B; PROLYL ENDOPEPTIDASE; SELECTIVE INHIBITOR; MESSENGER-RNA; IN-VITRO; A(2); EXPRESSION; PROTEIN;

D O I：

10.1007/s12272-015-0694-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) is enhanced by development of inflammatory disorders. In this study, sPLA2-IIA expression was induced in the lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells and mice to evaluate the effect of polyozellin. Polyozellin, a major constituent of a Korea edible mushroom Polyozellus multiplex, has been known to exhibit the biological activities such as anti-oxidative and anti-inflammatory effects. Polyozellin remarkably suppressed the LPS-mediated protein expression and activity of sPLA2-IIA via inhibition of phosphorylation of cytosolic phospholipase A2 and extracellular signal-regulated kinase 1/2. These results demonstrated that polyozellin might play an important role in the modulation of sPLA2-IIA expression and activity in response to the inflammatory diseases.

引用

页码：271 / 278

页数：8

共 50 条

[21] Effects of LDL Lipids on Activity of Group IIA Secretory Phospholipase A2
Samoilova, E. V.
Pirkova, A. A.
Prokazova, N. V.
Korotaeva, A. A.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2010, 150 (01) : 39 - 41
[22] Secretory phospholipase A2 group IIA modulates insulin sensitivity and metabolism
Kuefner, Michael S.
Pham, Kevin
Redd, Jeanna R.
Stephenson, Erin J.
Harvey, Innocence
Deng, Xiong
Bridges, Dave
Boilard, Eric
Elam, Marshall B.
Park, Edwards A.
JOURNAL OF LIPID RESEARCH, 2017, 58 (09) : 1822 - 1833
[23] Biological effects of secretory phospholipase A2 group IIA on lipoproteins and in atherogenesis
Jaross, W
Eckey, R
Menschikowski, M
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2002, 32 (06) : 383 - 393
[24] Halogenated phospholipids regulate secretory phospholipase A2 group IIA activity
Korotaeva, Aleksandra
Samoilova, Elena
Pavlunina, Tatyana
Panasenko, Oleg M.
CHEMISTRY AND PHYSICS OF LIPIDS, 2013, 167 : 51 - 56
[25] Group IIa secretory phospholipase A2 (sPLA2IIa) and progression in patients with lung cancer
Wang, M.
Hao, F-Y.
Wang, J-G.
Xiao, W.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2014, 18 (18) : 2648 - 2654
[26] Deterioration of axotomy-induced neurodegeneration by group IIA secretory phospholipase A2
Yagami, T
Ueda, K
Asakura, K
Hori, Y
BRAIN RESEARCH, 2001, 917 (02) : 230 - 234
[27] Expression of group IIa secretory phospholipase A2 increases with prostate tumor grade
Graff, JR
Konicek, BW
Deddens, JA
Chedid, M
Hurst, BM
Colligan, B
Neubauer, BL
Carter, HW
Carter, JH
CLINICAL CANCER RESEARCH, 2001, 7 (12) : 3857 - 3861
[28] Presence of secretory group IIa and V phospholipase A2 and cytosolic group IVα phospholipase A2 in chondrocytes from patients with rheumatoid arthritis
Leistad, L
Feuerherm, AJ
Ostensen, M
Faxvaag, A
Johansen, B
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2004, 42 (06) : 602 - 610
[29] A Concise Update on the Relevance of Secretory Phospholipase A2 Group IIA and its Inhibitors with Cancer
Chen, Juan
Ye, Long
Sun, Yu
Takada, Yoshikazhu
MEDICINAL CHEMISTRY, 2017, 13 (07) : 606 - 615
[30] Proapoptotic activity of secretory group IIA phospholipase A2 is regulated by nuclear factor κB
Liang, S
Herman, B
MOLECULAR BIOLOGY OF THE CELL, 2002, 13 : 162A - 162A

← 1 2 3 4 5 →