Mathematical Modeling of Human Ventricular Action Potentials

Modeling the dynamics of wave propagation in human ventricular tissue requires the use of specific ionic models, capable not only of reproducing key characteristics at single cell level, such as rate dependencies of human action potential duration, but also other tissue-level properties, such as rate dependence of conduction velocity, wave curvature, minimum rate for conduction block, or action potential morphologies. To date, only three different ionic models have been developed to reproduce human ventricular cell dynamics. The Priebe model, the Ten Tusscher model and the Iyer-Mazhari-Winslow model.