Towards a multi-electrode array (MEA) system for patterned neural networks

被引：4

作者：

Jing, Gaoshan ^{[1
]}

Yao, Yi ^{[1
]}

Gnerlich, Markus ^{[1
]}

Perry, Susan ^{[2
]}

Tatic-Lucic, Svetlana ^{[1
]}

机构：

[1] Lehigh Univ, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA

[2] Lehigh Univ, Dept Chem Engn, Bethlehem, PA 18015 USA

来源：

PROCEEDINGS OF THE EUROSENSORS XXIII CONFERENCE | 2009年 / 1卷 / 01期

基金：

美国国家科学基金会;

关键词：

multi-electrode array (MEA); cell patterning; self assembled monolayer (SAM); NEURONS;

D O I：

10.1016/j.proche.2009.07.082

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we describe the development of a unique multi-electrode array (MEA) system capable of supporting patterned neural networks in vitro. The significant features of this BioMEMS system are: (1) precise and exclusive positioning of the neural cell bodies to the electrode region, (2) definition of interconnecting pathways among the neurons by using patterned self-assembled monolayers (SAMs), and (3) one-to-one stimulation and recording from precisely positioned neurons. We present for the first time the design and fabrication of an MEA chip supporting patterned neuronal networks, as well as the initial electrical recordings from two types of neurons.

引用

页码：329 / +

页数：2

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