MicroRNA-1266 suppresses papillary thyroid carcinoma cell metastasis and growth via targeting FGFR2
被引:1
|
作者:
Fu, Y-T.
论文数: 0引用数: 0
h-index: 0
机构:
Jilin Univ, Dept Thyroid Surg, China Japan Union Hosp, Changchun, Jilin, Peoples R China
Jilin Prov Key Lab Surg Translat Med, Changchun, Jilin, Peoples R ChinaJilin Univ, Dept Thyroid Surg, China Japan Union Hosp, Changchun, Jilin, Peoples R China
Fu, Y-T.
[1
,2
]
Zheng, H. -B.
论文数: 0引用数: 0
h-index: 0
机构:
Jilin Univ, Dept Anesthesiol, Hosp 2, Changchun, Jilin, Peoples R ChinaJilin Univ, Dept Thyroid Surg, China Japan Union Hosp, Changchun, Jilin, Peoples R China
Zheng, H. -B.
[3
]
Zhang, D. -Q.
论文数: 0引用数: 0
h-index: 0
机构:
Jilin Univ, Dept Thyroid Surg, China Japan Union Hosp, Changchun, Jilin, Peoples R China
Jilin Prov Key Lab Surg Translat Med, Changchun, Jilin, Peoples R ChinaJilin Univ, Dept Thyroid Surg, China Japan Union Hosp, Changchun, Jilin, Peoples R China
Zhang, D. -Q.
[1
,2
]
Zhou, L.
论文数: 0引用数: 0
h-index: 0
机构:
Jilin Univ, Dept Thyroid Surg, China Japan Union Hosp, Changchun, Jilin, Peoples R China
Jilin Prov Key Lab Surg Translat Med, Changchun, Jilin, Peoples R ChinaJilin Univ, Dept Thyroid Surg, China Japan Union Hosp, Changchun, Jilin, Peoples R China
Zhou, L.
[1
,2
]
Sun, H.
论文数: 0引用数: 0
h-index: 0
机构:
Jilin Univ, Dept Thyroid Surg, China Japan Union Hosp, Changchun, Jilin, Peoples R China
Jilin Prov Key Lab Surg Translat Med, Changchun, Jilin, Peoples R ChinaJilin Univ, Dept Thyroid Surg, China Japan Union Hosp, Changchun, Jilin, Peoples R China
Sun, H.
[1
,2
]
机构:
[1] Jilin Univ, Dept Thyroid Surg, China Japan Union Hosp, Changchun, Jilin, Peoples R China
[2] Jilin Prov Key Lab Surg Translat Med, Changchun, Jilin, Peoples R China
[3] Jilin Univ, Dept Anesthesiol, Hosp 2, Changchun, Jilin, Peoples R China
OBJECTIVE: To explore the effects of microRNA-1266 (miR-1266) on metastasis and growth in papillary thyroid carcinoma cells and to provide therapeutic targets for papillary thyroid carcinoma. PATIENTS AND METHODS: By quantitative Real-time polymerase chain reaction (PCR), miR-1266 expression level in 38 pairs of papillary thyroid carcinoma tissues and three breast cancer-derived cell lines was examined. After transfection with miR-1266 mimics, the effects of miR-1266 over-expression on cell proliferation, invasion and migration were analyzed. Further, we employed several databases for the target gene prediction. Dual-luciferase activity assay was performed to verify whether FGFR2 was the direct target gene of miR-1266. Western blotting was conducted to detect protein levels. RESULTS: MiR-1266 was significantly down-regulated in papillary thyroid carcinoma tissue samples and cell lines. Over-expression of miR-1266 in papillary thyroid carcinoma cells significantly attenuated the cell proliferation, invasion, and migration. Dual-luciferase report assay and Western blotting confirmed that FGFR2 was a target gene of miR-1266. Furthermore, up-regulation of FGFR2 partially reversed the suppressive effects of miR-1266 over-expression on cell growth and progression. CONCLUSIONS: miR-1266 could inhibit cell proliferation and progression of papillary thyroid carcinoma via targeting FGFR2. Our findings might provide a new target for the diagnosis and treatment of papillary thyroid carcinoma.
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Endocrinol, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Endocrinol, Guangzhou 510080, Guangdong, Peoples R China
Yin, Yali
Hong, Shubin
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Endocrinol, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Endocrinol, Guangzhou 510080, Guangdong, Peoples R China
Hong, Shubin
Yu, Shuang
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Endocrinol, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Endocrinol, Guangzhou 510080, Guangdong, Peoples R China
Yu, Shuang
Huang, Yanrui
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Endocrinol, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Endocrinol, Guangzhou 510080, Guangdong, Peoples R China
Huang, Yanrui
Chen, Shuwei
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Canc Ctr, Dept Head & Neck Surg, Guangzhou 510060, Guangdong, Peoples R China
Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Endocrinol, Guangzhou 510080, Guangdong, Peoples R China
Chen, Shuwei
Liu, Yujie
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Breast Tumor Ctr, Guangzhou 510120, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Endocrinol, Guangzhou 510080, Guangdong, Peoples R China
Liu, Yujie
Zhang, Quan
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Canc Ctr, Dept Head & Neck Surg, Guangzhou 510060, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Endocrinol, Guangzhou 510080, Guangdong, Peoples R China
Zhang, Quan
Li, Yanbing
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Endocrinol, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Endocrinol, Guangzhou 510080, Guangdong, Peoples R China
Li, Yanbing
Xiao, Haipeng
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Endocrinol, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Endocrinol, Guangzhou 510080, Guangdong, Peoples R China
机构:
China US Henan Hormel Canc Inst, 127 Dongming Rd, Zhengzhou 450008, Henan, Peoples R ChinaChina US Henan Hormel Canc Inst, 127 Dongming Rd, Zhengzhou 450008, Henan, Peoples R China
Shi, Yuanyuan
Liu, Xuejiao
论文数: 0引用数: 0
h-index: 0
机构:
China US Henan Hormel Canc Inst, 127 Dongming Rd, Zhengzhou 450008, Henan, Peoples R ChinaChina US Henan Hormel Canc Inst, 127 Dongming Rd, Zhengzhou 450008, Henan, Peoples R China
Liu, Xuejiao
Fredimoses, Mangaladoss
论文数: 0引用数: 0
h-index: 0
机构:
China US Henan Hormel Canc Inst, 127 Dongming Rd, Zhengzhou 450008, Henan, Peoples R ChinaChina US Henan Hormel Canc Inst, 127 Dongming Rd, Zhengzhou 450008, Henan, Peoples R China
Fredimoses, Mangaladoss
Song, Mengqiu
论文数: 0引用数: 0
h-index: 0
机构:
China US Henan Hormel Canc Inst, 127 Dongming Rd, Zhengzhou 450008, Henan, Peoples R China
Zhengzhou Univ, Sch Basic Med Sci, Dept Pathophysiol, Zhengzhou, Henan, Peoples R ChinaChina US Henan Hormel Canc Inst, 127 Dongming Rd, Zhengzhou 450008, Henan, Peoples R China
Song, Mengqiu
Chen, Hanyong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Minnesota, Hormel Inst, 801 16th Ave NE, Austin, MN 55912 USAChina US Henan Hormel Canc Inst, 127 Dongming Rd, Zhengzhou 450008, Henan, Peoples R China
Chen, Hanyong
Liu, Kangdong
论文数: 0引用数: 0
h-index: 0
机构:
China US Henan Hormel Canc Inst, 127 Dongming Rd, Zhengzhou 450008, Henan, Peoples R China
Zhengzhou Univ, Sch Basic Med Sci, Dept Pathophysiol, Zhengzhou, Henan, Peoples R ChinaChina US Henan Hormel Canc Inst, 127 Dongming Rd, Zhengzhou 450008, Henan, Peoples R China
Liu, Kangdong
Lee, Mee-Hyun
论文数: 0引用数: 0
h-index: 0
机构:
China US Henan Hormel Canc Inst, 127 Dongming Rd, Zhengzhou 450008, Henan, Peoples R ChinaChina US Henan Hormel Canc Inst, 127 Dongming Rd, Zhengzhou 450008, Henan, Peoples R China
Lee, Mee-Hyun
Dong, Zigang
论文数: 0引用数: 0
h-index: 0
机构:
China US Henan Hormel Canc Inst, 127 Dongming Rd, Zhengzhou 450008, Henan, Peoples R China
Univ Minnesota, Hormel Inst, 801 16th Ave NE, Austin, MN 55912 USAChina US Henan Hormel Canc Inst, 127 Dongming Rd, Zhengzhou 450008, Henan, Peoples R China