Possible common origin of α-fetoprotein- and human chorionic gonadotropin-secreting cells in intracranial germ cell tumor -: Case report

被引：3

作者：

Kishima, H ^{[1
]}

Shimizu, K ^{[1
]}

Miyao, Y ^{[1
]}

Mabuchi, E ^{[1
]}

Hayakawa, T ^{[1
]}

机构：

[1] Osaka Univ, Sch Med, Dept Neurosurg, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF NEUROSURGERY | 1998年 / 88卷 / 03期

关键词：

germ cell tumor; alpha-fetoprotein; human chorionic gonadotropin;

D O I：

10.3171/jns.1998.88.3.0576

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A primary intracranial germ cell tumor in a 16-year-old boy secreted both cl-fetoprotein (AFP) and human chorionic gonadotropin (HCG). The tumor, located in the right thalamus, contained germinomatous, trophoblastic, and endodermal sinus components. To identify AFP-and HCG-secreting cells, germ cells from the surgical specimen were cultured in vitro. These cultured cells secreted AFP and HCG for 10 weeks, and immunohistochemical studies showed that some of the cells secreted both AFP and HCG. These findings suggest that multipotential germ cells migrate to the encephalic region and may become germ cell tumors containing various types of tissue.

引用

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页码：576 / 580

页数：5

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