Aurora kinase inhibitors

被引：73
|
作者：
Kitzen, J. J. E. M. [1 ]
de Jonge, M. J. A. [1 ]
Verweij, J. [1 ]
机构：
[1] Erasmus Univ, Med Ctr, Dept Med Oncol, NL-3075 EA Rotterdam, Netherlands
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2010年 / 73卷 / 02期
关键词：
Aurora kinase; Aurora kinase inhibitor; Aurora-A; Aurora-B; Aurora-C; Pre-clinical; Phase I; CHROMOSOMAL PASSENGER PROTEIN; AMPLIFICATION; REVEALS; YEAST; GENE; MCAK; PHOSPHORYLATION; IDENTIFICATION; PHOSPHATASE-1; ASSOCIATION;
D O I：
10.1016/j.critrevonc.2009.03.009
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Most human cancer cells are characterized by changes in the amount or organization of DNA resulting in chromosome instability and aneuploidy. Several mitotic kinases, Aurora kinases amongst others, regulate the progression of the cell through mitosis. So far three Aurora kinases have been identified in man: Aurora-A, Aurora-B and Aurora-C. Aurora kinases were recently identified as a potential target in anticancer therapy, and various Aurora-A and Aurora-B kinase inhibitors are in development. In this review we provide a brief insight into the mechanism of action as far as currently available. We review the available pre-clinical data, discuss the clinical phase I data and try to give a direction for future headings. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：99 / 110
页数：12
相关论文
共 50 条
  • [41] Aurora kinase A inhibitors: promising agents in antitumoral therapy
    Malumbres, Marcos
    Perez de Castro, Ignacio
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2014, 18 (12) : 1377 - 1393
  • [42] Mitotic drivers-inhibitors of the Aurora B Kinase
    Keen, Nicholas
    Taylor, Stephen
    CANCER AND METASTASIS REVIEWS, 2009, 28 (1-2) : 185 - 195
  • [43] QSAR studies on imidazopyrazine derivatives as Aurora A kinase inhibitors
    Leng, Y.
    Lu, T.
    Yuan, H. L.
    Liu, H. C.
    Lu, S.
    Zhang, W. W.
    Jiang, Y. L.
    Chen, Y. D.
    SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2012, 23 (7-8) : 705 - 730
  • [44] Molecular docking/dynamics studies of Aurora A kinase inhibitors
    Talele, Tanaji T.
    McLaughlin, Mark L.
    JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2008, 26 (08): : 1213 - 1222
  • [45] Synthesis and characterization of pyrazoleanthrone derivatives as Aurora A kinase inhibitors
    Sun Xiao-xiao
    Sun Tao
    Wang Tai-yi
    Zhang Yan
    Liu Hui-juan
    Wang Quan
    Niu Guo-jun
    Liu Wei
    Zhou Hong-gang
    Yang Cheng
    CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2013, 29 (06) : 1098 - 1103
  • [46] A comprehension on synthetic strategies of Aurora kinase A and B inhibitors
    Priya
    Jaswal, Shalini
    Gupta, Ghanshyam Das
    Verma, Sant Kumar
    JOURNAL OF MOLECULAR STRUCTURE, 2023, 1278
  • [47] Aurora kinase inhibitors: identification and preclinical validation of their biomarkers
    Carpinelli, Patrizia
    Moll, Juergen
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2008, 12 (01) : 69 - 80
  • [48] 2-Aminobenzimidazoles as potent Aurora kinase inhibitors
    Zhong, Min
    Bui, Minna
    Shen, Wang
    Baskaran, Subramanian
    Allen, Darin A.
    Elling, Robert A.
    Flanagan, W. Michael
    Fung, Amy D.
    Hanan, Emily J.
    Harris, Shannon O.
    Heumann, Stacey A.
    Hoch, Ute
    Ivy, Sheryl N.
    Jacobs, Jeffrey W.
    Lam, Stuart
    Lee, Heman
    McDowell, Robert S.
    Oslob, Johan D.
    Purkey, Hans E.
    Romanowski, Michael J.
    Silverman, Jeffrey A.
    Tangonan, Bradley T.
    Taverna, Pietro
    Yang, Wenjin
    Yoburn, Josh C.
    Yu, Chul H.
    Zimmerman, Kristin M.
    O'Brien, Tom
    Lew, Willard
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (17) : 5158 - 5161
  • [49] The potential role of Aurora kinase inhibitors in haematological malignancies
    Farag, Sherif S.
    BRITISH JOURNAL OF HAEMATOLOGY, 2011, 155 (05) : 561 - 579
  • [50] A field guide to Aurora kinase inhibitors: an oocyte perspective
    Blengini, Cecilia S.
    Jung, Gyu Ik
    Aboelenain, Mansour
    Schindler, Karen
    REPRODUCTION, 2022, 164 (04) : V5 - V7
12345