This article extends computational models of schizophrenia that focus on the negative aspects of this syndrome to behavioral biases that are associated with a positive symptom of schizophrenia, namely delusions. The phenomenon studied is the "jump-to-conclusions" style of reasoning that is characterized by delusional patients-in comparison with controls-whereby they make less-informed decisions when an option to collect more decision-specific information is available. Simulations show that these differences can be min-ticked by modulating the gain parameter-associated with variations in dopamine level-in a simple network model.
机构:
Cent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
Cent S Univ, Mental Hlth Ctr, Xiangya Hosp, Changsha, Hunan, Peoples R ChinaCent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
Liu, Haihong
Kaneko, Yoshio
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Yale Univ, Sch Med, New Haven, CT USACent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
Kaneko, Yoshio
Ouyang, Xuan
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Cent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R ChinaCent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
Ouyang, Xuan
Li, Li
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Cent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R ChinaCent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
Li, Li
Hao, Yihui
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Cent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R ChinaCent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
Hao, Yihui
Chen, Eric Y. H.
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Univ Hong Kong, Fac Med, Dept Psychiat, Hong Kong, Hong Kong, Peoples R ChinaCent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
Chen, Eric Y. H.
Jiang, Tianzi
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Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing, Peoples R ChinaCent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
Jiang, Tianzi
Zhou, Yuan
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Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing, Peoples R China
Chinese Acad Sci, Inst Psychol, Ctr Social & Econ Behav, Beijing 100101, Peoples R ChinaCent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
Zhou, Yuan
Liu, Zhening
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Cent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R ChinaCent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
机构:
UCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, EnglandUCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
Evans, Simon
Almahdi, Basil
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Univ Coll Hosp, London, EnglandUCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
Almahdi, Basil
Sultan, Pervez
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Univ Coll Hosp, London, EnglandUCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
Sultan, Pervez
Sohanpal, Imrat
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Univ Coll Hosp, London, EnglandUCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
Sohanpal, Imrat
Brandner, Brigitta
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Univ Coll Hosp, London, EnglandUCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
Brandner, Brigitta
Collier, Tracey
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机构:UCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
Collier, Tracey
Shergill, Sukhi S.
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Kings Coll London, Inst Psychiat, Dept Psychiat, Cognit Schizophrenia & Imaging Lab, London, EnglandUCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
Shergill, Sukhi S.
Cregg, Roman
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Univ Coll Hosp, London, EnglandUCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
Cregg, Roman
Averbeck, Bruno B.
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UCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
NIMH, Neuropsychol Lab, NIH, Bethesda, MD 20892 USAUCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
机构:
Fed Med Res Ctr Psychiat & Narcol, Kropotkinsky Lane 23, Moscow 119034, RussiaFed Med Res Ctr Psychiat & Narcol, Kropotkinsky Lane 23, Moscow 119034, Russia
Kirenskaya, Anna, V
Storozheva, Zinaida, I
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Fed Med Res Ctr Psychiat & Narcol, Kropotkinsky Lane 23, Moscow 119034, RussiaFed Med Res Ctr Psychiat & Narcol, Kropotkinsky Lane 23, Moscow 119034, Russia
Storozheva, Zinaida, I
Gruden, Marina A.
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Fed State Budgetary Sci Inst, PK Anokhin Res Inst Normal Physiol, Baltiskaya St 8, Moscow 125315, RussiaFed Med Res Ctr Psychiat & Narcol, Kropotkinsky Lane 23, Moscow 119034, Russia
Gruden, Marina A.
Sewell, Robert D. E.
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Cardiff Univ, Cardiff Sch Pharm & Pharmaceut Sci, Redwood Bldg, Cardiff CF10 3NB, S Glam, WalesFed Med Res Ctr Psychiat & Narcol, Kropotkinsky Lane 23, Moscow 119034, Russia