Studies on the antifungal activity of biotemplated gold nanoparticles over Candida albicans

被引：13
|
作者：
Nidhin, M. [1 ]
Saneha, D. [2 ]
Hans, Sandeep [3 ]
Varghese, Anitha [1 ]
Fatima, Zeeshan [3 ]
Hameed, Saif [3 ]
机构：
[1] CHRIST Deemed Be Univ, Dept Chem, Bengaluru 560029, Karnataka, India
[2] Amity Univ Haryana Amity Educ Valley, Amity Sch Appl Sci, Dept Chem, Gurgaon 122413, Haryana, India
[3] Amity Univ Haryana, Amity Inst Biotechnol, Amity Educ Valley, Gurgaon 122413, Haryana, India
来源：
MATERIALS RESEARCH BULLETIN | 2019年 / 119卷
关键词：
Gold nanoparticles; Antifungal activity; Candida albicans; Micro dilution assay; Green synthesis; SIZE;
D O I：
10.1016/j.materresbull.2019.110563
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Green synthesis and applications of gold nanoparticles are more fascinating research area due to their unique optical properties and high X-ray attenuation power. In this study, we have synthesized gold nanoparticles of uniform size (5 nm) with spherical shape. UV-vis spectroscopy, Transmission Electron Microscopy and Atomic Force Microscopy were employed to characterize the synthesized gold nanoparticles. The biomedical applications of the synthesized gold nanoparticles were carried out against most prevalent human fungal pathogen, Candida albicans. Broth micro dilution assay was used to determine minimum inhibitory concentration (MIC). We observed that 0. 5 mM concentration was effective in inhibiting the growth of fungal cells which was later confirmed by spot assay.
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页数：5
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