The Role of TNF-α as a Proinflammatory Cytokine in Pathological Processes

被引：27
|
作者：
Silva, Luciano B. [1 ]
dos Santos Neto, Alexandrino P. [2 ]
Maia, Sandra M. A. S. [1 ]
Guimaraes, Carolina dos Santos [1 ]
Quidute, Iliana L. [1 ]
Carvalho, Alessandra de A. T. [2 ]
Junior, Severino A. [3 ]
Leao, Jair C. [2 ]
机构：
[1] Univ Pernambuco UPE, Dept Endodont, 1650 Gal Ne Wton Cavalcanti Ave, BR-54753020 Camaragibe, PE, Brazil
[2] Fed Univ Pernambuco UFPE, Dept Clin & Prevent Dent, Hlth Sci Ctr, 1235 Prof Moraes Rego St, BR-50670901 Recife, PE, Brazil
[3] Fed Univ Pernambuco UFPE, Exact & Nat Sci Ctr, Dept Fundamental Chem, Prof Luis Freire St, BR-50740540 Recife, PE, Brazil
来源：
OPEN DENTISTRY JOURNAL | 2019年 / 13卷
关键词：
Tumor necrosis factor; Inflammation; Cytokine(s); Leucocytes; Antigen Presenting Cells (APCs); Interferon (IFN); TUMOR-NECROSIS-FACTOR; TRANSMEMBRANE TNF; CROHNS-DISEASE; MYOCARDIAL-INFARCTION; APICAL PERIODONTITIS; RADICULAR CYSTS; RECEPTOR; MECHANISMS; INFLIXIMAB; EXPRESSION;
D O I：
10.2174/1874210601913010332
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
TNF-alpha is a member of the vast cytokine family being considered a proinflammatory substance produced many by macrophages and other cells belonging to the innate immunity, many of them classified as indeed Antigen Presenting Cells (APCs) involved in the complex chemotactic process of activation of the adaptive immunity. The aim of this work was to accomplish a literature review concerning the main pathologies that have TNF-alpha as a modulating agent in other to bring light to the main interactions present in the inflammation installed.
引用
收藏
页码：332 / 338
页数：7
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