Determination of amphetamine-derived designer drugs in human urine by SPE extraction and capillary electrophoresis with mass spectrometry detection

被引：56
|
作者：
Boatto, G [1 ]
Nieddu, M [1 ]
Carta, A [1 ]
Pau, A [1 ]
Palomba, M [1 ]
Asproni, B [1 ]
Cerri, R [1 ]
机构：
[1] Univ Sassari, Dipartimento Farm Chim Tossicol, I-07100 Sassari, Italy
来源：
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2005年 / 814卷 / 01期
关键词：
methylenedioxy-derivates; amphetamine; phenylethylamine; designer drug; urine; capillary electrophoresis; mass spectrometry; solid-phase extraction (SPE);
D O I：
10.1016/j.jchromb.2004.10.010
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
In recent years, a number of newer designer drugs have entered the illicit drug market. The methylenedioxy-derivates of amphetamine represent the largest group of designer drugs. This paper describes a method for screening for and quantification of ten 2,5-methylenedioxy-derivates of amphetamine and phenylethylamine in human urine, using capillary electrophoresis coupled to electrospray ionisation-mass spectrometry (CE-ESI-MS). Prior to CE-MS analysis, a simple solid-phase extraction (SPE) was used for sample cleanup. The method was validates according to international guidelines. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：93 / 98
页数：6
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