Cefiderocol as Rescue Therapy for Acinetobacter baumannii and Other Carbapenem-resistant Gram-negative Infections in Intensive Care Unit Patients

被引：99

作者：

Falcone, Marco ^{[1
]}

Tiseo, Giusy ^{[1
]}

Nicastro, Manuela ^{[2
]}

Leonildi, Alessandro ^{[3
]}

Vecchione, Alessandra ^{[3
]}

Casella, Costanza ^{[2
]}

Forfori, Francesco ^{[2
,4
]}

Malacarne, Paolo ^{[2
]}

Guarracino, Fabio ^{[2
]}

Barnini, Simona ^{[3
]}

Menichetti, Francesco ^{[1
]}

机构：

[1] Univ Pisa, Infect Dis Azienda Osped Univ Pisana, Dept Clin & Expt Med, Pisa, Italy

[2] Azienda Osped Univ Pisana, Dept Anaesthesia & Crit Care Med, Pisa, Italy

[3] Azienda Osped Univ Pisana, Microbiol Unit, Pisa, Italy

[4] Univ Pisa, Dept Surg Med & Mol Pathol & Crit Care Med, Pisa, Italy

来源：

CLINICAL INFECTIOUS DISEASES | 2021年 / 72卷 / 11期

关键词：

cefiderocol; ICU; Acinetobacter baumannii; metallo-beta-lactamases; NDM-producing Klebsiella pneumoniae;

D O I：

10.1093/cid/ciaa1410

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ten critically ill patients with either bacteremia or ventilator-associated pneumonia caused by carbapenem-resistant Acinetobacter baumannii, Stenotrophomonas maltophilia, or New Delhi metallo-beta-lactamase-producing Klebsiella pneumoniae received cefiderocol. All strains had minimum in- hibitory concentration <= 2 mu g/mL. Thirty-day clinical success and survival rates were 70% and 90%, respectively. Two patients had a microbiological failure. Future prospective studies are warranted.

引用

页码：2021 / 2024

页数：4

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