Cefiderocol as Rescue Therapy for Acinetobacter baumannii and Other Carbapenem-resistant Gram-negative Infections in Intensive Care Unit Patients

被引：99

作者：

Falcone, Marco ^{[1
]}

Tiseo, Giusy ^{[1
]}

Nicastro, Manuela ^{[2
]}

Leonildi, Alessandro ^{[3
]}

Vecchione, Alessandra ^{[3
]}

Casella, Costanza ^{[2
]}

Forfori, Francesco ^{[2
,4
]}

Malacarne, Paolo ^{[2
]}

Guarracino, Fabio ^{[2
]}

Barnini, Simona ^{[3
]}

Menichetti, Francesco ^{[1
]}

机构：

[1] Univ Pisa, Infect Dis Azienda Osped Univ Pisana, Dept Clin & Expt Med, Pisa, Italy

[2] Azienda Osped Univ Pisana, Dept Anaesthesia & Crit Care Med, Pisa, Italy

[3] Azienda Osped Univ Pisana, Microbiol Unit, Pisa, Italy

[4] Univ Pisa, Dept Surg Med & Mol Pathol & Crit Care Med, Pisa, Italy

来源：

CLINICAL INFECTIOUS DISEASES | 2021年 / 72卷 / 11期

关键词：

cefiderocol; ICU; Acinetobacter baumannii; metallo-beta-lactamases; NDM-producing Klebsiella pneumoniae;

D O I：

10.1093/cid/ciaa1410

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ten critically ill patients with either bacteremia or ventilator-associated pneumonia caused by carbapenem-resistant Acinetobacter baumannii, Stenotrophomonas maltophilia, or New Delhi metallo-beta-lactamase-producing Klebsiella pneumoniae received cefiderocol. All strains had minimum in- hibitory concentration <= 2 mu g/mL. Thirty-day clinical success and survival rates were 70% and 90%, respectively. Two patients had a microbiological failure. Future prospective studies are warranted.

引用

页码：2021 / 2024

页数：4

共 50 条

[1] Education: An overview from the author of `Cefiderocol as rescue therapy for Acinetobacter baumannii and other carbapenem-resistant Gram-negative infections in intensive care unit patients'
Falcone, Marco
[J]. JAC-ANTIMICROBIAL RESISTANCE, 2021, 3 : 25 - 25
[2] Education: An overview from the author of 'Cefiderocol as rescue therapy for Acinetobacter baumannii and other carbapenem-resistant Gram-negative infections in intensive care unit patients' (vol 3, pg 25, 2021)
Marco, Falcone
[J]. JAC-ANTIMICROBIAL RESISTANCE, 2021, 3 (03):
[3] Case series of cefiderocol for salvage therapy in carbapenem-resistant Gram-negative infections
Gavaghan, Victoria
Miller, Jessica L.
Dela-Pena, Jennifer
[J]. INFECTION, 2023, 51 (02) : 475 - 482
[4] Case series of cefiderocol for salvage therapy in carbapenem-resistant Gram-negative infections
Victoria Gavaghan
Jessica L. Miller
Jennifer Dela-Pena
[J]. Infection, 2023, 51 : 475 - 482
[5] Carbapenem-resistant Acinetobacter baumannii: A challenge in the intensive care unit
Jiang, Yuan
Ding, Yinhuan
Wei, Yueshuai
Jian, Chunxia
Liu, Jinbo
Zeng, Zhangrui
[J]. FRONTIERS IN MICROBIOLOGY, 2022, 13
[6] Carbapenem-resistant Acinetobacter baumannii contamination in an intensive care unit
Ferreira Raro, Otavio Hallal
Gallo, Stephanie Wagner
Sanchez Ferreira, Carlos Alexandre
de Oliveira, Sivia Dias
[J]. REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 2017, 50 (02) : 167 - 172
[7] Risk factors for carbapenem-resistant Gram-negative bacteremia in intensive care unit patients
Routsi, Christina
Pratikaki, Maria
Platsouka, Evangelia
Sotiropoulou, Christina
Papas, Vasileios
Pitsiolis, Theodoros
Tsakris, Athanassios
Nanas, Serafeim
Roussos, Charis
[J]. INTENSIVE CARE MEDICINE, 2013, 39 (07) : 1253 - 1261
[8] Risk factors for carbapenem-resistant Gram-negative bacteremia in intensive care unit patients
Christina Routsi
Maria Pratikaki
Evangelia Platsouka
Christina Sotiropoulou
Vasileios Papas
Theodoros Pitsiolis
Athanassios Tsakris
Serafeim Nanas
Charis Roussos
[J]. Intensive Care Medicine, 2013, 39 : 1253 - 1261
[9] Frequency of cefiderocol heteroresistance among patients treated with cefiderocol for carbapenem-resistant Acinetobacter baumannii infections
Shields, Ryan K.
Dorazio, Ava J.
Tiseo, Giusy
Squires, Kevin M.
Leonildi, Alessandro
Giordano, Cesira
Kline, Ellen G.
Barnini, Simona
Iovleva, Alina
Griffith, Marissa P.
Van Tyne, Daria
Doi, Yohei
Falcone, Marco
[J]. JAC-ANTIMICROBIAL RESISTANCE, 2024, 6 (05):
[10] Endemicity and diversification of carbapenem-resistant Acinetobacter baumannii in an intensive care unit
Doughty, Emma L.
Liu, Haiyang
Moran, Robert A.
Hua, Xiaoting
Ba, Xiaoliang
Guo, Feng
Chen, Xiangping
Zhang, Linghong
Holmes, Mark
van Schaik, Willem
Mcnally, Alan
Yu, Yunsong
[J]. LANCET REGIONAL HEALTH-WESTERN PACIFIC, 2023, 37

← 1 2 3 4 5 →