COVID-19 susceptibility and clinical outcomes in autoimmune inflammatory rheumatic diseases (AIRDs): a systematic review and meta-analysis

被引：0

作者：

Shin, J., I ^{[1
]}

Kim, S. E. ^{[2
]}

Lee, M. H. ^{[2
]}

Kim, M. S. ^{[3
]}

Lee, S. W. ^{[4
,5
]}

Park, S. ^{[2
]}

Shin, Y. H. ^{[6
]}

Yang, J. W. ^{[7
]}

Song, J. M. ^{[8
]}

Moon, S. Y. ^{[4
]}

Kim, S. Y. ^{[9
]}

Park, Y. ^{[2
]}

Suh, D., I ^{[10
]}

Yang, J. M. ^{[11
,12
]}

Cho, S. H. ^{[13
]}

Jin, H. Y. ^{[4
]}

Hong, S. H. ^{[2
]}

Won, H-H ^{[14
]}

Kronbichler, A. ^{[15
]}

Koyanagi, A. ^{[16
,17
]}

Jacob, L. ^{[16
,18
]}

Hwang, J. ^{[19
]}

Tizaoui, K. ^{[20
]}

Lee, K. H. ^{[1
]}

Kim, J. H. ^{[1
,21
]}

Yon, D. K. ^{[4
,22
]}

Smith, L. ^{[23
]}

机构：

[1] Yonsei Univ, Dept Pediat, Coll Med, Seoul, South Korea

[2] Yonsei Univ, Coll Med, Seoul, South Korea

[3] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol SAIHST, Seoul, South Korea

[4] Sejong Univ, Dept Data Sci, Coll Software Convergence, Seoul, South Korea

[5] Sungkyunkwan Univ, Sch Med, Suwon, South Korea

[6] CHA Univ, CHA Gangnam Med Ctr, Dept Pediat, Sch Med, Seoul, South Korea

[7] Yonsei Univ, Dept Nephrol, Wonju Coll Med, Wonju, South Korea

[8] Keimyung Univ, Sch Med, Daegu, South Korea

[9] CHA Univ, Sch Med, CHA Bundang Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Seongnam, South Korea

[10] Seoul Natl Univ, Dept Pediat, Coll Med, Seoul, South Korea

[11] Univ Ulsan, Asan Med Ctr, Dept Ophthalmol, Coll Med, Seoul, South Korea

[12] Dongguk Univ, Dept Ophthalmol, Ilsan Hosp, Goyang, South Korea

[13] Univ S Florida, Morsani Coll Med, Div Allergy Immunol, Tampa, FL 33620 USA

[14] Sungkyunkwan Univ, Samsung Med Ctr, Samsung Adv Inst Hlth Sci & Technol SAIHST, Seoul, South Korea

[15] Univ Cambridge, Dept Med, Cambridge, England

[16] CIBERSAM, Parc Sanitari St Joan de Deu, Res & Dev Unit, Barcelona, Spain

[17] ICREA Catalan Inst Res & Adv Studies, Barcelona, Spain

[18] Univ Versailles St Ouentin En Yvelines, Fac Med, Montigny Le Bretonneux, France

[19] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[20] Tunis El Manar Univ, Med Fac Tunis, Dept Basic Sci, Tunis, Tunisia

[21] Yonsei Univ, Gangnam Severance Hosp, Dept Pediat, Coll Med, Seoul, South Korea

[22] Kyung Hee Univ, Coll Med, Med Sci Res Inst, Ctr Digital Hlth, Seoul, South Korea

[23] Anglia Ruskin Univ, Ctr Hlth Performance & Wellbeing, Cambridge, England

来源：

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2022年 / 26卷 / 10期

关键词：

Autoimmune inflammatory rheumatic disease; COVID-19; SARS-CoV-2; Steroid; Connective tissue disease; Inflammatory arthritis; Disease-modifying anti-rheumatic drugs; INFECTION; ARTHRITIS; RISK; HOSPITALIZATION;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

OBJECTIVE: This meta-analysis aims to assess the susceptibility to and clinical outcomes of COVID-19 in autoimmune inflammatory rheumatic disease (AIRD) and following AIRD drug use. MATERIALS AND METHODS: We included observational and case-controlled studies assessing susceptibility and clinical outcomes of COVID-19 in patients with AIRD as well as the clinical outcomes of COVID-19 with or with- out use of steroids and conventional synthetic disease-modifying antirheumatic drugs (csDMARDs). RESULTS: Meta-analysis including three studies showed that patients with AIRD are not more susceptible to COVID-19 compared to patients without AIRD or the general population (OR: 1.11. 95% CI: 0.58 to 2.14). Incidence of severe outcomes of COVID-19 (OR: 1.34. 95% CI: 0.76 to 2.35) and COVID-19 related death (OR: 1.21. 95% CI: 0.68 to 2.16) also did not show significant difference. The clinical outcomes of COVID-19 among AIRD patients with and without csDMARD or steroid showed that both use of steroid (OR: 1.69. 95% CI: 0.96 to 2.98) or csDMARD (OR: 1.35, 95% CI: 0.63 to 3.08) had no effect on clinical outcomes of COVID-19. CONCLUSIONS: AIRD does not increase susceptibility to COVID-19. not affecting the clinical outcome of COVID-19. Similarly, the use of steroids or csDMARDs for AIRD does not worsen the clinical outcome.

引用

页码：3760 / 3770

页数：11

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