Genetic approaches at the neuromuscular synapse are leading investigation into the mechanisms of synaptogenesis. The marriage of classical (forward) and reverse genetic techniques allows the isolation and analysis of novel proteins involved in synaptic maturation and the functional in vivo characterization of previously identified synaptic proteins. Of particular interest are recent advances using mouse reverse genetics and Drosophila forward genetics.
机构:National Science Foundation Science and Technology Center for Biological Timing, Department of Neurobiology and Physiology, Northwestern University, Evanston
TAKAHASHI, JS
PINTO, LH
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机构:National Science Foundation Science and Technology Center for Biological Timing, Department of Neurobiology and Physiology, Northwestern University, Evanston
PINTO, LH
VITATERNA, MH
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机构:National Science Foundation Science and Technology Center for Biological Timing, Department of Neurobiology and Physiology, Northwestern University, Evanston
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Peking Univ, Coll Life Sci, Minist Educ, Key Lab Cell Proliferat & Differentiat, Beijing 100871, Peoples R ChinaUniv Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA
Huang, Peng
Zhu, Zuoyan
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Peking Univ, Coll Life Sci, Minist Educ, Key Lab Cell Proliferat & Differentiat, Beijing 100871, Peoples R ChinaUniv Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA
Zhu, Zuoyan
Lin, Shuo
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Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA
Lin, Shuo
Zhang, Bo
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Peking Univ, Coll Life Sci, Minist Educ, Key Lab Cell Proliferat & Differentiat, Beijing 100871, Peoples R ChinaUniv Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA
Peng HuangaZuoyan ZhuaShuo LinbBo Zhanga a Key Laboratory of Cell Proliferation and Differentiation of Ministry of EducationCollege of Life SciencesPeking UniversityBeijing China b Department of MolecularCell Developmental BiologyUniversity of CaliforniaLos AngelesCA USA
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Peng HuangaZuoyan ZhuaShuo LinbBo Zhanga a Key Laboratory of Cell Proliferation and Differentiation of Ministry of EducationCollege of Life SciencesPeking UniversityBeijing China b Department of MolecularCell Developmental BiologyUniversity of CaliforniaLos AngelesCA USA