LncRNA SBF2-AS1 Promotes Diffuse Large B-Cell Lymphoma Growth by Regulating FGFR2 via Sponging miR-494-3p

被引：12
|
作者：
Fu, Dong-Wei [1 ]
Liu, Ai-Chun [1 ]
机构：
[1] Harbin Med Univ, Dept Hematol, Canc Hosp, Harbin 150081, Heilongjiang, Peoples R China
来源：
CANCER MANAGEMENT AND RESEARCH | 2021年 / 13卷
关键词：
diffuse large B-cell lymphoma; SBF2-AS1; miR-494-3p; FGFR2; tumorigenesis; EXPRESSION; CANCER; BIOMARKER; RECEPTOR; DNA;
D O I：
10.2147/CMAR.S284258
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose: Currently, there is no efficient and feasible method for diffuse large B-cell lymphoma (DLBCL) in clinical practice, and the main reason is the unclear pathogenesis of DLBCL, which leads to a high fatality rate of DLBCL. Methods: Therefore, it is meaningful to explore the molecular mechanism of DLBCL and find a targeted therapeutic approach from the molecular level. Results: Long non-coding RNA (lncRNA) SBF2-AS1 was highly expressed in DLBCL tissues and cell lines. Silencing of SBF2-AS1 inhibited the viability and growth of OCI-LY-3 cells. Furthermore, SBF2-AS1 acted as a sponge of miR-494-3p and inhibited its expression. And miR-494-3p directly targeted FGFR2. Functionally, forced expression of miR-494-3p or knockdown of FGFR2 removed the promoted effects of lncRNA SBF2-AS1 on DLBCL development. In vivo tumorigenesis experiments indicated SBF2-AS1 accelerated tumor growth via miR-494-3p/FGFR2 axis. Conclusion: Our study revealed that SBF2-AS1 promoted the growth of DLBCL, which were mediated by miR-494-3p/FGFR2 axis.
引用
收藏
页码：571 / 578
页数：8
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