Maternal obesity alters the apelinergic system at the feto-maternal interface

被引：14

作者：

Hanssens, Sandy ^{[1
,2
]}

Marx-Deseure, Aurore ^{[1
,2
]}

Lecoutre, Simon ^{[3
]}

Butruille, Laura ^{[2
]}

Fournel, Audren ^{[4
]}

Knauf, Claude ^{[4
]}

Besengez, Capucine ^{[2
]}

Breton, Christophe ^{[3
]}

Storme, Laurent ^{[1
,5
]}

Deruelle, Philippe ^{[1
,2
]}

Lesage, Jean ^{[3
]}

机构：

[1] CHRU Lille, Jeanne Flandre Hosp, Gynecol Obstet, F-59037 Lille, France

[2] Univ Lille, Unite Environm Perinatal & Sante, EA 4489, Fac Med,Pole Rech,IFR 114, F-59045 Lille, France

[3] Univ Lille 1, EA 4489, F-59655 Villeneuve Dascq, France

[4] INSERM, Inst Malad Metabol & Cardiovasc I2MC, Team 3, U1048, F-31432 Toulouse, France

[5] CHRU Lille, Jeanne Flandre Hosp, Neonatal Reanimat, Lille, France

来源：

PLACENTA | 2016年 / 39卷

关键词：

Maternal obesity; Apelin; APJ; Fetus; Placenta; Mice; TISSUE DISTRIBUTION; APJ; LIGAND;

D O I：

10.1016/j.placenta.2016.01.006

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Apelin and its receptor APJ have been implicated in pathologies including cardiovascular disease, diabetes and obesity. Little is known about the function of the apelinergic system during gestation. We evaluated in mice this system at the feto-maternal interface in insulin-resistant obese female (HF) mice. Maternal apelinemia was decreased at term and fetal apelinemia was sixfold higher than maternal level. Ex-vivo, the placenta releases apelin at E12.5 and E18.5. In HF pregnant mice at term, apelinemia as well as placental apelin and APJ mRNA levels were increased whereas placental release of apelin was drastically reduced compared to controls. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：41 / 44

页数：4

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