Maternal obesity alters the apelinergic system at the feto-maternal interface

被引：14
|
作者：
Hanssens, Sandy [1 ,2 ]
Marx-Deseure, Aurore [1 ,2 ]
Lecoutre, Simon [3 ]
Butruille, Laura [2 ]
Fournel, Audren [4 ]
Knauf, Claude [4 ]
Besengez, Capucine [2 ]
Breton, Christophe [3 ]
Storme, Laurent [1 ,5 ]
Deruelle, Philippe [1 ,2 ]
Lesage, Jean [3 ]
机构：
[1] CHRU Lille, Jeanne Flandre Hosp, Gynecol Obstet, F-59037 Lille, France
[2] Univ Lille, Unite Environm Perinatal & Sante, EA 4489, Fac Med,Pole Rech,IFR 114, F-59045 Lille, France
[3] Univ Lille 1, EA 4489, F-59655 Villeneuve Dascq, France
[4] INSERM, Inst Malad Metabol & Cardiovasc I2MC, Team 3, U1048, F-31432 Toulouse, France
[5] CHRU Lille, Jeanne Flandre Hosp, Neonatal Reanimat, Lille, France
来源：
PLACENTA | 2016年 / 39卷
关键词：
Maternal obesity; Apelin; APJ; Fetus; Placenta; Mice; TISSUE DISTRIBUTION; APJ; LIGAND;
D O I：
10.1016/j.placenta.2016.01.006
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Apelin and its receptor APJ have been implicated in pathologies including cardiovascular disease, diabetes and obesity. Little is known about the function of the apelinergic system during gestation. We evaluated in mice this system at the feto-maternal interface in insulin-resistant obese female (HF) mice. Maternal apelinemia was decreased at term and fetal apelinemia was sixfold higher than maternal level. Ex-vivo, the placenta releases apelin at E12.5 and E18.5. In HF pregnant mice at term, apelinemia as well as placental apelin and APJ mRNA levels were increased whereas placental release of apelin was drastically reduced compared to controls. (C) 2016 Elsevier Ltd. All rights reserved.
引用
下载
收藏
页码：41 / 44
页数：4
相关论文
共 50 条
  • [1] Maternal adaptation to vasculogenesis and angiogenesis at the feto-maternal interface
    Yagel, S
    Goldman-Wohl, DS
    Mandelboim, O
    Hanna, Y
    Hochner-Celnikier, D
    THROMBOSIS RESEARCH, 2005, 115 : 97 - 99
  • [2] Dynamics of immunoglobulins at the feto-maternal interface
    Saji, F
    Samejima, Y
    Kamiura, S
    Koyama, M
    REVIEWS OF REPRODUCTION, 1999, 4 (02): : 81 - 89
  • [3] Cytokine network at the feto-maternal interface
    Saito, S
    JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2000, 47 (02) : 87 - 103
  • [4] Feto-Maternal Consequences of Obesity in Pregnancy
    Inam, Iram
    Ul Hassan, Ghias
    Bibi, Nagina
    PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES, 2021, 15 (12): : 3407 - 3409
  • [5] Methylome of Fetal and Maternal Monocytes and Macrophages at the Feto-Maternal Interface
    Kim, Sun Young
    Romero, Roberto
    Tarca, Adi L.
    Bhatti, Gaurav
    Kim, Chong Jai
    Lee, JoonHo
    Elsey, Amelia
    Than, Nandor Gabor
    Chaiworapongsa, Tinnakorn
    Hassan, Sonia S.
    Kang, Gyeong Hoon
    Kim, Jung-Sun
    AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2012, 68 (01) : 8 - 27
  • [6] Unprecedented communication of microRNAs at the feto-maternal interface
    Chang, Guojing
    Sadovsky, Yoel
    Mouillet, Jean-Francois
    Mishima, Takuya
    Ouyang, Yingshi
    Chu, Tianjiao
    Coyne, Carolyn
    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2014, 210 (01) : S93 - S94
  • [7] Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface
    Colette Kanellopoulos-Langevin
    Stéphane M Caucheteux
    Philippe Verbeke
    David M Ojcius
    Reproductive Biology and Endocrinology, 1 (1)
  • [8] Review: Relaxin expressed at the feto-maternal interface
    Klonisch, T
    Hombach-Klonisch, S
    REPRODUCTION IN DOMESTIC ANIMALS, 2000, 35 (3-4) : 149 - 152
  • [9] FETO-MATERNAL TRANSFUSION
    KENNEDY, I
    BRITISH MEDICAL JOURNAL, 1972, 2 (5815): : 715 - &
  • [10] VEGF system detection in feto-maternal interface in Iberian pig implantation
    Sanchez, M.
    Garcia-Palencia, P.
    Sanchez, B.
    Palomo, A.
    Ruiz-Gonzalez, I.
    Garcia-Fernandez, R.
    Flores, J.
    REPRODUCTION IN DOMESTIC ANIMALS, 2012, 47 : 107 - 107
12345