Copper-catalyzed gem-difluoromethylenation of C(sp2)-H bonds of alkenes

被引：19
|
作者：
Xu, Hui [1 ]
Wang, Dejing [1 ]
Chen, Yunrong [1 ]
Wan, Wen [1 ]
Deng, Hongmei [2 ]
Ma, Kesen [3 ]
Wu, Shaoxiong [4 ]
Hao, Jian [1 ,5 ]
Jiang, Haizhen [1 ,5 ]
机构：
[1] Shanghai Univ, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China
[2] Shanghai Univ, Lab Microstruct, Shanghai 200444, Peoples R China
[3] Univ Waterloo, Dept Biol, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada
[4] Emory Univ, Emory NMR Res Ctr, 201 Dowman Dr, Atlanta, GA 30322 USA
[5] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2017年 / 4卷 / 07期
基金：
中国国家自然科学基金;
关键词：
C-H FUNCTIONALIZATION; TERMINAL ALKENES; RECENT PROGRESS; TRIFLUOROMETHYLATION; DIFLUOROACETYLATION; FLUOROALKYLATION; INHIBITORS; CHEMISTRY; ARYLATION; FLUORINE;
D O I：
10.1039/c7qo00119c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Copper-catalyzed gem-difluoromethylenation of the C(sp(2))-H bonds of alkenes with high functional group tolerance has been developed. This protocol is the first to efficiently achieve gem-difluoromethylenation of C(sp(2))-H bonds of unactivated aliphatic terminal olefins and can be applied in a reaction cascade to achieve gem-difluoromethylenation/cyclization of alkenes.
引用
收藏
页码：1239 / 1243
页数：5
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