The aim of this non-randomized pilot study was to assess whether serial casting can be used in Duchenne muscular dystrophy (DMD) patients to reduce tendo-achilles (TA) contractures and to allow the fitting of the knee-ankle-foot orthoses (KAFOs) at the end of the functional walking. TA range and age at loss of standing with KAFOs were prospectively assessed in nine DMD patients who underwent serial casting prior to rehabilitation into KAFOs and compared to a group of 20 DMD patients who had TA (group II) or TA and iliotibial band (ITB) surgical resection (group III). TA range after casting was reduced at least to plantargrade/neutral in 8 of the 9 patients studied although patients who had surgery had better correction of TA angles. The mean interval between rehabilitation and loss of standing ability with KAFOs was only minimally different among the three groups 1.8 years (9 months-2.8 years) in group I, 2 years (1 month-4.3 years) in group II, 1.9 years (6 months-4.7 years) in group III. The results of this pilot study suggest that serial casting of the TAs can be considered in DMD patients with moderate TA contractures and in whom there are no significant iliotibial band (ITB) tightness, although this intervention is probably not as effective as surgery in maintaining long-term TA range. This procedure may therefore be considered both in patients with medical contraindication to surgery, and also in patients or families who are not prepared to cope with the stress and discomfort of TA surgery. (C) 2006 Elsevier B.V. All rights reserved.
机构:
Kobe Gakuin Univ, Res Ctr Locomot Biol, Nishi Ku, Kobe, Hyogo 6512180, JapanKobe Gakuin Univ, Res Ctr Locomot Biol, Nishi Ku, Kobe, Hyogo 6512180, Japan
Matsuo, Masafumi
Awano, Hiroyuki
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Kobe Univ, Grad Sch Med, Dept Pediat, Chuo Ku, Kobe, Hyogo 6500017, JapanKobe Gakuin Univ, Res Ctr Locomot Biol, Nishi Ku, Kobe, Hyogo 6512180, Japan
Awano, Hiroyuki
Nishio, Hisahide
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Kobe Gakuin Univ, Res Ctr Locomot Biol, Nishi Ku, Kobe, Hyogo 6512180, JapanKobe Gakuin Univ, Res Ctr Locomot Biol, Nishi Ku, Kobe, Hyogo 6512180, Japan
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Ctr Duchenne Muscular Dystrophy, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA
Wang, Richard T.
Nelson, Stanley F.
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Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Ctr Duchenne Muscular Dystrophy, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA
机构:
Hosp St Joan Deu, Dept Neurol, Neuromuscular Unit, Barcelona, SpainHosp St Joan Deu, Dept Neurol, Neuromuscular Unit, Barcelona, Spain
Gomez, J. Armijo
Liz, M.
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Hosp St Joan Deu, Dept Neurol, Epilepsy Unit, Barcelona, SpainHosp St Joan Deu, Dept Neurol, Neuromuscular Unit, Barcelona, Spain
Liz, M.
Ortez, C.
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Hosp St Joan Deu, Dept Neurol, Neuromuscular Unit, Barcelona, Spain
Inst Recerca St Joan Deu, Appl Res Neuromuscular Dis, Barcelona, Spain
ISCIII, Ctr Biomed Res Network Rare Dis CIBERER, Barcelona, SpainHosp St Joan Deu, Dept Neurol, Neuromuscular Unit, Barcelona, Spain
Ortez, C.
Dominguez-Carral, J.
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Hosp St Joan Deu, Dept Neurol, Epilepsy Unit, Barcelona, SpainHosp St Joan Deu, Dept Neurol, Neuromuscular Unit, Barcelona, Spain
Dominguez-Carral, J.
Exposito-Escudero, J.
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Hosp St Joan Deu, Dept Neurol, Neuromuscular Unit, Barcelona, Spain
Inst Recerca St Joan Deu, Appl Res Neuromuscular Dis, Barcelona, SpainHosp St Joan Deu, Dept Neurol, Neuromuscular Unit, Barcelona, Spain
Exposito-Escudero, J.
Carrera-Garcia, L.
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Hosp St Joan Deu, Dept Neurol, Neuromuscular Unit, Barcelona, Spain
Inst Recerca St Joan Deu, Appl Res Neuromuscular Dis, Barcelona, SpainHosp St Joan Deu, Dept Neurol, Neuromuscular Unit, Barcelona, Spain
Carrera-Garcia, L.
Natera De Benito, D.
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Hosp St Joan Deu, Dept Neurol, Neuromuscular Unit, Barcelona, Spain
Inst Recerca St Joan Deu, Appl Res Neuromuscular Dis, Barcelona, SpainHosp St Joan Deu, Dept Neurol, Neuromuscular Unit, Barcelona, Spain
Natera De Benito, D.
Nascimento, A.
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Hosp St Joan Deu, Dept Neurol, Neuromuscular Unit, Barcelona, Spain
Inst Recerca St Joan Deu, Appl Res Neuromuscular Dis, Barcelona, Spain
ISCIII, Ctr Biomed Res Network Rare Dis CIBERER, Barcelona, SpainHosp St Joan Deu, Dept Neurol, Neuromuscular Unit, Barcelona, Spain