Nephroprotective Effect of EDL Peptide at Acute Injury of Kidneys of Different Genesis

被引：5
|
作者：
Zamorskii, I. I. [1 ]
Shchudrova, T. S. [1 ]
Lin'kova, N. S. [2 ,3 ]
Nichik, T. E. [2 ]
Khavinson, V. Kh. [2 ,4 ]
机构：
[1] Bukovinian State Med Univ, Chernovtsy, Ukraine
[2] St Petersburg Inst Bioregulat & Gerontol, St Petersburg, Russia
[3] Peter Great St Petersburg Polytechn Univ, St Petersburg, Russia
[4] Russian Acad Sci, IP Pavlov Inst Physiol, St Petersburg, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2017年 / 163卷 / 03期
关键词：
acute kidney damage injury; EDL peptide; nephroprotection; ACUTE-RENAL-FAILURE; MECHANISMS;
D O I：
10.1007/s10517-017-3811-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
EDL peptide produced a nephroprotective effect on experimental models gentamycin-induced nephropathy and ischemia/reperfusion kidney injury in rats. The nephroprotective effect of EDL peptide manifested in prevention of oliguria and retention azotemia, a decrease in proteinuria and sodium excretion, prevention of critical decrease in activities of antioxidant enzymes, suppression of LPO, and normalization of energy supply to kidneys cells. Our findings confirm the prospects of further studies of the nephroprotective properties of peptide EDL in various pathologies of the kidneys.
引用
收藏
页码：389 / 393
页数：5
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