A diplotype in the lymphotoxin alpha gene is associated with differential expression of LTA mRNA induced by Gram-positive and Gram-negative bacteria

被引：4
|
作者：
Temple, S. E. L.
Almeida, C. M.
Cheong, K. Y.
Wunderink, R. G.
Waterer, G. W.
机构：
[1] Univ Western Australia, Royal Perth Hosp, Sch Med & Pharmacol, Perth, WA 6847, Australia
[2] Northwestern Univ, Feinberg Sch Med, Div Pulm & Crit Care, Chicago, IL USA
来源：
INTERNATIONAL JOURNAL OF IMMUNOGENETICS | 2007年 / 34卷 / 03期
关键词：
D O I：
10.1111/j.1744-313X.2007.00674.x
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We sequenced the lymphotoxin alpha (LTA) promoter and identified LTA10G>A in strong linkage with LTA252G>A and LTA723C>A. Stimulated cells from LTA723AA: LTA252GG:LTA10AA individuals had significantly higher LTA mRNA levels than LTA723CC:LTA252AA:LTA10GG and LTA723AA:LTA252AG:LTA10GA individuals, suggesting that this diplotype may contain a functional polymorphism explaining the observed disease associations with LTA252G>A.
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页码：157 / 160
页数：4
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