Drug-resistant tuberculosis epidemic in the Western Cape driven by a virulent Beijing genotype strain

被引：0
|
作者：
Johnson, R. [1 ]
Warren, R. M. [1 ]
van der Spuy, G. D. [1 ]
Gey van Pittius, N. C. [1 ]
Theron, D. [2 ]
Streicher, E. M. [1 ]
Bosman, M. [3 ]
Coetzee, G. J. [3 ]
van Helden, P. D. [1 ]
Victor, T. C. [1 ]
机构：
[1] Univ Stellenbosch, Div Mol Biol & Human Genet, MRC Ctr Mol & Cellular Biol,Dept Biomed Sci, DST,NRF Ctr Excellence Biomed TB Res,Fac Hlth Sci, ZA-7505 Tygerberg, South Africa
[2] Brewelskloof Hosp, MDR Unit, Worcester, MA USA
[3] Natl Hlth Lab Serv, Cape Town, South Africa
来源：
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2010年 / 14卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
drug resistance; Mycobacterium tuberculosis; Beijing genotype; MYCOBACTERIUM-TUBERCULOSIS; SOUTH-AFRICA;
D O I：
暂无
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Temporal analysis of drug-resistant tuberculosis (TB) cases in the Western Cape, South Africa, showed a 1.5-fold increase over a 2-year period, suggesting a doubling time of 8.2 years. This increase was strongly associated with multidrug resistance and the Beijing genotype. Forty-two per cent of the overall increase was due to the Beijing genotype strain R220, suggesting that this strain had evolved unique properties that allowed for both acquisition and transmission of drug resistance. To curb the drug-resistant TB epidemic in this setting, it will be essential to implement rapid diagnostics and efficient infection control measures, improve contact screening and ensure treatment adherence.
引用
收藏
页码：119 / 121
页数：3
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