Expression of sulfotransferase IEI in human prostate as studied by in situ hybridization and immunocytochemistry

被引：12
|
作者：
Takase, Y.
Luu-The, V.
Poisson-Pare, D.
Labrie, F.
Pelletier, G.
机构：
[1] CHU Laval, Res Ctr, Oncol & Mol Endocrinol Lab, Quebec City, PQ G1V 4G2, Canada
[2] Kanazawa Univ, Dept Urol, Kanazawa, Ishikawa 920, Japan
来源：
PROSTATE | 2007年 / 67卷 / 04期
关键词：
sulfotransf erase 1E1; benign prostate hyperplasia; estrogen; in situ hybridization; immunocytochemistry;
D O I：
10.1002/pros.20525
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
BACKGROUND. Estrogen is recognized to play a role in the development and function of the prostate. Estrogen sulfotransferase (EST) 1E1 catalyzes the sulfoconjugation of estrogen and is thus involved in the metabolism of estrogen. We have recently shown that EST 1E1 is highly expressed in male mouse reproductive organs, including prostate. It appeared of interest to study the expression of EST I El in human prostate. METHODS. EST 1E1 mRNA and protein expression was evaluated in benign prostatic hyperplasia (BPH) using in situ hybridization and immunocytochemistry, respectively. RESULTS. EST 1E1 mRNA and protein were found to be expressed in epithelial cells bordering alveola lumen (luminal cells) as well as stroma cells. CONCLUSION. The enzyme EST may play a physiological role in regulating local estrogen levels in human prostate.
引用
收藏
页码：405 / 409
页数：5
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