Variants of CARD15/NOD2 associated with Crohn's disease and blau syndrome differ from wild type NOD2 in regulating cytokine secretion induced by TLR2 and TLR4 agonists in a transduced macrophage cell line

被引:0
|
作者
Davey, Michael
Zhang, Zili
Martin, Tammy
Rosenzweig, Holly
Planck, Steven
Rosenbaum, James
机构
[1] Oregon Hlth & Sci Univ, Portland VA Med Ctr, Portland, OR 97201 USA
[2] Oregon Hlth & Sci Univ, Portland, OR 97201 USA
[3] Oregon Hlth & Sci Univ, CEI, Portland, OR 97201 USA
[4] Oregon Hlth & Sci Univ, Casey Eye Inst, Portland, OR 97201 USA
关键词
D O I
10.1016/j.clim.2007.03.024
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:S135 / S136
页数:2
相关论文
共 50 条
  • [31] NOD2/Card15 mutations in Crohn's disease are associated with young age at diagnosis and ileal location
    Louis, E
    Hugot, JP
    Colombel, JF
    Fontaine, F
    Delforge, M
    Belaiche, J
    GASTROENTEROLOGY, 2002, 122 (04) : A295 - A295
  • [32] NOD2/CARD15 gene variants are linked to failure of antibiotic treatment in perianal fistulating Crohn's disease
    Angelberger, Sieglinde
    Reinisch, Walter
    Dejaco, Clemens
    Miehsler, Wolfgang
    Waldhoer, Thomas
    Wehkamp, Jan
    Lichtenberger, Cornelia
    Schaeffeler, Elke
    Vogelsang, Harald
    Schwab, Matthias
    Teml, Alexander
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2008, 103 (05): : 1197 - 1202
  • [33] NOD2/CARD15 gene variants are linked to failure of antibiotic treatment in perianal fistulating Crohn's disease
    Teml, A.
    Reinisch, W.
    Dejaco, C.
    Waldhoer, T.
    Lichtenberger, C.
    Schaeffeler, E.
    Vogelsang, H.
    Schwab, M.
    Angelberger, S.
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2007, 101 (05) : 383 - 383
  • [34] Upper gastrointestinal involvement in patients with Crohn's disease is strongly associated with double dose of the NOD2/CARD15 allelic variants
    Mardini, HE
    Gregory, K
    Selby, L
    Winter, TA
    de Villiers, WJS
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2004, 99 (10): : S253 - S253
  • [35] Crohn's disease patients homozygous for the 3020insC NOD2 mutation have a defective NOD2/TLR4 cross-tolerance to intestinal stimuli
    Kullberg, Bart Jan
    Ferwerda, Gerben
    de Jong, Dirk J.
    Drenth, Joost P. H.
    Joosten, Leo A. B.
    Van der Meer, Jos W. M.
    Netea, Mihai G.
    IMMUNOLOGY, 2008, 123 (04) : 600 - 605
  • [36] Regulation of IL-10 production induced by NOD2/CARD15 and TLR2 pathways in human monocyte-derived dendritic cells
    Li, J. N.
    Hedl, Matija
    Mohseni, Morassa
    Qato, Kholil
    Yilmaz, Betul
    Bracamonte, Samuel
    Abraham, Clara
    Cho, Judy
    GASTROENTEROLOGY, 2006, 130 (04) : A231 - A231
  • [37] Mutations in the NOD2/CARD15 gene in Crohn's disease are associated with ileocecal resection and are a risk factor for reoperation
    Büning, C
    Genschel, J
    Bühner, S
    Krüger, S
    Kling, K
    Dignass, A
    Baier, P
    Bochow, B
    Ockenga, J
    Schmidt, HHJ
    Lochs, H
    ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2004, 19 (10) : 1073 - 1078
  • [38] MDP-Induced Selective Tolerance to TLR4 Ligands: Impairment in NOD2 Mutant Crohn's Disease Patients
    Canto, Elisabet
    Moga, Esther
    Ricart, Elena
    Garcia-Bosch, Orlando
    Garcia-Planella, Esther
    Juarez, Candido
    Vidal, Silvia
    INFLAMMATORY BOWEL DISEASES, 2009, 15 (11) : 1686 - 1696
  • [39] Do NOD2/CARD15 variants explain the high prevalence of early-onset Crohn's disease in Scotland?
    Russell, R
    Drummond, H
    Nimmo, E
    Smith, L
    Anderson, N
    Gillett, P
    Wilson, D
    Weaver, L
    Mcgrogan, P
    Hassan, K
    Bisset, M
    Mahdi, C
    Satsangi, J
    GASTROENTEROLOGY, 2005, 128 (04) : A493 - A493
  • [40] Do NOD2/CARD15 variants explain the high prevalence of early-onset Crohn's disease in Scotland?
    Russell, RK
    Drummond, H
    Smith, L
    Anderson, N
    Nimmo, ER
    Wilson, DC
    Gillett, PM
    McGrogan, P
    Hassan, K
    Weaver, LT
    Bisset, M
    Mahdi, G
    Satsangi, J
    GUT, 2005, 54 : A96 - A96