Autoimmune diseases: MIF as a therapeutic target

被引：68
|
作者：
Greven, Dorothee [1 ]
Leng, Lin [2 ]
Bucala, Richard [2 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Div Clin Immunol & Rheumatol, NL-1105 AZ Amsterdam, Netherlands
[2] Yale Univ, Rheumatol Sect, New Haven, CT 06510 USA
来源：
EXPERT OPINION ON THERAPEUTIC TARGETS | 2010年 / 14卷 / 03期
关键词：
MIGRATION-INHIBITORY FACTOR; JUVENILE IDIOPATHIC ARTHRITIS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; FACTOR GENE POLYMORPHISM; INNATE IMMUNE-RESPONSES; RHEUMATOID-ARTHRITIS; REGULATORY ROLE; PROINFLAMMATORY FUNCTION; PROMOTER POLYMORPHISMS; CRYSTAL-STRUCTURE;
D O I：
10.1517/14728220903551304
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Areas covered in this review: Our aim is to discuss MIF-directed therapies as a novel therapeutic approach. The review covers literature from the past 10 years. What the reader will gain: MIF inhibition has been shown to be efficacious in many experimental and pre-clinical studies of autoimmune inflammatory diseases. The close regulatory relationship between MIF and glucocorticoids makes therapeutic antagonism of MIF a potential steroid-sparing therapy in patients with refractory autoimmune diseases. Take home message: We expect that MIF antagonism by either small-molecule- or antibody-based approaches will find wide application in the treatment of autoimmune inflammatory diseases. Such therapy also may be informed by the MIF genotype of affected patients.
引用
收藏
页码：253 / 264
页数：12
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