Novel deoxy-selenylconduritols: chemoenzymatic synthesis and biological evaluation

被引：10
|
作者：
Bellomo, Ana [1 ]
Bertucci, Ana [2 ]
Stefani, Helio [3 ,4 ]
Vazquez, Alvaro [2 ]
Gonzalez, David [1 ]
机构：
[1] Univ Republica, UdelaR, Fac Quim, Lab Sintesis Organ, Montevideo, Uruguay
[2] Univ Republica, UdelaR, Fac Quim, Lab Farmacognosia & Prod Nat, Montevideo, Uruguay
[3] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Sao Paulo, Brazil
[4] Univ Fed Sao Paulo, Dept Biofis, Sao Paulo, Brazil
来源：
TETRAHEDRON-ASYMMETRY | 2009年 / 20卷 / 23期
基金：
巴西圣保罗研究基金会;
关键词：
EFFICIENT SYNTHESIS; (-)-CONDURITOL C; CONDURITOL; CYCLITOLS; SELENIUM; CONDURAMINE; DERIVATIVES; HYDROLYSIS; EPOXIDES; ANALOGS;
D O I：
10.1016/j.tetasy.2009.11.004
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The first synthesis of two selenyldeoxycyclitols (4-bromo-2-phenylselenyl conduritol F and 6-phenylselenylconduritol F) is reported via a chemoenzymatic enantioselective route. The key step of the synthesis is the selenolysis of a vinyl epoxide. The new compounds were evaluated for their capacity to inhibit the growth of different microorganisms using a modification of the agar diffusion technique with thin layer chromatography plates as support. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2673 / 2676
页数：4
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