Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes

被引：38
|
作者：
Chen, Wenqing [1 ,2 ]
Qi, Jianzhao [1 ,2 ]
Wu, Pan [1 ,2 ]
Wan, Dan [1 ,2 ]
Liu, Jin [1 ,2 ]
Feng, Xuan [1 ,2 ]
Deng, Zixin [1 ,2 ,3 ,4 ]
机构：
[1] Wuhan Univ, Minist Educ, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Peoples R China
[2] Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China
[3] Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200030, Peoples R China
[4] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200030, Peoples R China
来源：
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY | 2016年 / 43卷 / 2-3期
基金：
美国国家科学基金会;
关键词：
Nucleoside antibiotics; Natural products; Post-genomic era; Synthetic biology; BACTERIAL TRANSLOCASE-I; STREPTOMYCES-TENDAE TU901; GENE-CLUSTER; HETEROLOGOUS EXPRESSION; NIKKOMYCIN BIOSYNTHESIS; MOLECULAR ANALYSIS; PACIDAMYCIN GROUP; BOND FORMATION; PUR CLUSTER; IDENTIFICATION;
D O I：
10.1007/s10295-015-1636-3
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Nucleoside antibiotics constitute an important family of microbial natural products bearing diverse bioactivities and unusual structural features. Their biosynthetic logics are unique with involvement of complex multi-enzymatic reactions leading to the intricate molecules from simple building blocks. Understanding how nature builds this family of antibiotics in post-genomic era sets the stage for rational enhancement of their production, and also paves the way for targeted persuasion of the cell factories to make artificial designer nucleoside drugs and leads via synthetic biology approaches. In this review, we discuss the recent progress and perspectives on the natural and engineered biosynthesis of nucleoside antibiotics.
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页码：401 / 417
页数：17
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