Since Coleman's studies, lipofilling has become an easy, reliable and reproducible surgical technique particularly in severe Romberg's syndrome that is characterised by a progressive facial hemi-atrophy of cutaneous and subcutaneous tissues. Considering a young patient case, the authors expose a rare complication of lipofilling: deterioration of the aesthetic results after a significative weight gain due to corticosteroids, oral contraception and a change of lifestyle. Lipofilling is an adipocyte graft realised after centrifugation of liposuction products. Thus, the increasing volume of the fat graft remains hypertrophic and hyperplasic theories. Indeed, the technique produces a concentrated fat graft that realises an asymmetry of fat distribution in both sides of the face. The authors present their preliminary results. (C) 2009 Published by Elsevier Masson SAS.