Additional targets of the Bacillus subtilis global regulator CodY identified by chromatin immunoprecipitation and genome-wide transcript analysis

被引：243
|
作者：
Molle, V
Nakaura, Y
Shivers, RP
Yamaguchi, H
Losick, R
Fujita, Y
Sonenshein, AL
机构：
[1] Tufts Univ, Sch Med, Dept Mol Biol & Microbiol, Boston, MA 02111 USA
[2] Harvard Univ, Dept Cellular & Mol Biol, Cambridge, MA 02138 USA
[3] Fukuyama Univ, Fac Engn, Fukuyama, Hiroshima 72902, Japan
来源：
JOURNAL OF BACTERIOLOGY | 2003年 / 185卷 / 06期
关键词：
D O I：
10.1128/JB.185.6.1911-1922.2003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Additional targets of CodY, a GTP-activated repressor of early stationary-phase genes in Bacillus subtilis, were identified by combining chromatin immunoprecipitation, DNA microarray hybridization, and gel mobility shift assays. The direct targets of CodY newly identified by this approach included regulatory genes for sporulation, genes that are likely to encode transporters for amino acids and sugars, and the genes for biosynthesis of branched-chain amino acids.
引用
收藏
页码：1911 / 1922
页数：12
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