Assessment of the antibiofilm and antiquorum sensing activities of Eucalyptus globulus essential oil and its main component 1,8-cineole against methicillin-resistant Staphylococcus aureus strains

被引：119
|
作者：
Merghni, Abderrahmen [1 ,2 ]
Noumi, Emira [1 ]
Hadded, Ons [1 ,3 ]
Dridi, Neyla [1 ]
Panwar, Harsh [4 ]
Ceylan, Ozgur [5 ]
Mastouri, Maha [1 ,3 ]
Snoussi, Mejdi [6 ]
机构：
[1] Univ Monastir, Fac Pharm, Lab Transmissible Dis & Biol Act Subst, Monastir, Tunisia
[2] Univ Tunis El Manar, Fac Med Tunis, Dept Basic Sci B, Lab Microbiol, Tunis, Tunisia
[3] Fattouma Bourguiba Univ Hosp, Lab Microbiol, Monastir, Tunisia
[4] GADVASU, Coll Dairy Sci & Technol, Dept Dairy Microbiol, Ludhiana, Punjab, India
[5] Mugla Sitki Kocman Univ, Ula Ali Kocman Vocat Sch, Mugla, Turkey
[6] Univ Monastir, High Inst Biotechnol, Lab Genet Biodivers & Valorisat Bioresources, Monastir, Tunisia
来源：
MICROBIAL PATHOGENESIS | 2018年 / 118卷
关键词：
MRSA; Biofilm; Eucalyptus globulus; 1,8-Cineole; Antibacterial; Antiquorum sensing; CHEMICAL-COMPOSITION; ANTIMICROBIAL ACTIVITY; SLIME PRODUCTION; BIOFILM; INFECTIONS; ANTIOXIDANT; ANTIBACTERIAL; EPIDERMIDIS; INHIBITION; DISEASE;
D O I：
10.1016/j.micpath.2018.03.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Antibacterial resistance is an increasingly serious threat to global public health. The search for new anti-infection agents from natural resources, with different mode of actions and competitive effects became a necessity. In this study, twenty height methicillin-resistant Staphylococcus aureus (MRSA) strains were investigated for their biofilm formation ability. Subsequently, the antibiofilm effects of Eucalyptus globulus essential oil and its main component 1,8-cineole, against MRSA, as well as their antiquorum sensing potential, were evaluated. Our results displayed the potent efficacy of both E. globulus essential oil and 1,8-cineole against the development of biofilms formed by the methicillin-resistant strains. Additionally, E. globulus essential oil showed more potent of anti-QS activity, even at a low concentration, when compared to 1,8-cineole. All these property of tested agents may pave the way to prevent the development of biofilm formation by MRSA and subsequently the spreading of nosocomial infection.
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收藏
页码：74 / 80
页数：7
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