Effects of printing conditions on cell distribution within microspheres during inkjet-based bioprinting

被引:28
|
作者
Xu, Heqi [1 ]
Casillas, Jazzmin [2 ]
Xu, Changxue [1 ]
机构
[1] Texas Tech Univ, Dept Ind Mfg & Syst Engn, Lubbock, TX 79409 USA
[2] Texas Tech Univ, Dept Mech Engn, Lubbock, TX 79409 USA
基金
美国国家科学基金会;
关键词
SILK FIBROIN; TISSUE; CONSTRUCTS;
D O I
10.1063/1.5116371
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Inkjet-based bioprinting have been widely employed in a variety of applications in tissue engineering and drug screening and delivery. The typical bioink used in inkjet bioprinting consists of biological materials and living cells. During inkjet bioprinting, the cell-laden bioink is ejected out from the inkjet dispenser to form microspheres with cells encapsulated. The cell distribution within microspheres is defined as the distribution of cell number within the microspheres. The paper focuses on the effects of polymer concentration, excitation voltage, and cell concentration on the cell distribution within microspheres during inkjet printing of cell-laden bioink. The normal distribution has been utilized to fit the experimental results to obtain the mean and standard deviation of the distribution. It is found that the cell distribution within the microspheres increases with the increase of the cell concentration, sodium alginate concentration, and the excitation voltage.
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页数:10
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