SAFETY, TOLERABILITY AND PHARMACOKINETICS OF THE NOVEL CATHEPSIN K INHIBITOR, ONO-5334, IN POSTMENOPAUSAL WOMEN: AN ASCENDING SINGLE AND MULTIPLE DOSE PHASE I STUDY

被引:0
|
作者
Nagase, S. [1 ]
Hashimoto, Y. [2 ]
Ohyama, M. [3 ]
Kuwayama, T. [1 ]
Deacon, S. [1 ]
机构
[1] Ono Pharma UK Ltd, London, England
[2] Ono Pharmaceut Co Ltd, Tsukuba, Ibaraki, Japan
[3] Ono Pharmaceut Co Ltd, Osaka, Japan
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:339 / 339
页数:1
相关论文
共 50 条
  • [31] Phase 1b single and multiple ascending dose study to evaluate the safety, tolerability and pharmacokinetics of HT-100 in DMD
    Escolar, D. M.
    Davis-Golden, J.
    Loewy, J.
    Bush, E.
    Dykstra, K.
    Blaustein, M.
    NEUROMUSCULAR DISORDERS, 2013, 23 (9-10) : 802 - 803
  • [32] Phase 1 Single and Multiple Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AG-946 in Healthy Volunteers
    Merica, VarshaIyer Elizabeth
    Ronseaux, Sebastien
    Gamache, Tressa
    Mulrow, Nancy J.
    Belcijan, Anja
    Callaghan, Michael U.
    BLOOD, 2021, 138
  • [33] A phase I ascending single-dose study of the safety, tolerability, and pharmacokinetics of bosutinib (SKI-606) in healthy adult subjects
    Abbas, Richat
    Hug, Bruce A.
    Leister, Cathie
    El Gaaloul, Myriam
    Chalon, Stephan
    Sonnichsen, Daryl
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2012, 69 (01) : 221 - 227
  • [34] A phase I ascending single-dose study of the safety, tolerability, and pharmacokinetics of bosutinib (SKI-606) in healthy adult subjects
    Richat Abbas
    Bruce A. Hug
    Cathie Leister
    Myriam El Gaaloul
    Stephan Chalon
    Daryl Sonnichsen
    Cancer Chemotherapy and Pharmacology, 2012, 69 : 221 - 227
  • [35] Phase I single and multiple dose study to evaluate the safety, tolerability, and pharmacokinetics of BMS-927711 in healthy subjects
    G Tong
    I Savant
    N Jariwala
    D Burt
    N Zheng
    A Buzescu
    R Bertz
    S Keswani
    R Marcus
    The Journal of Headache and Pain, 2013, 14
  • [36] Phase I single and multiple dose study to evaluate the safety, tolerability, and pharmacokinetics of BMS-927711 in healthy subjects
    Tong, G.
    Savant, I.
    Jariwala, N.
    Burt, D.
    Zheng, N.
    Buzescu, A.
    Bertz, R.
    Keswani, S.
    Marcus, R.
    JOURNAL OF HEADACHE AND PAIN, 2013, 14
  • [37] Safety, Tolerability, and Pharmacokinetics of PF-06823859, an Anti-Interferon β Monoclonal Antibody: A Randomized, Phase I, Single- and Multiple-Ascending-Dose Study
    Neelakantan, Srividya
    Oemar, Barry
    Johnson, Kristen
    Rath, Natalie
    Salganik, Mikhail
    Berman, Gabe
    Pelletier, Kathleen
    Cox, Lori
    Page, Karen
    Messing, Dean
    Tarabar, Sanela
    CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2021, 10 (03): : 307 - 316
  • [38] Single- and Multiple-Ascending-Dose Study of the Safety, Tolerability, and Pharmacokinetics of the Polymyxin Derivative SPR206
    Bruss, Jon
    Lister, Troy
    Gupta, Vipul K.
    Stone, Emily
    Morelli, Lisa
    Lei, Yang
    Melnick, David
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021, 65 (10)
  • [39] Safety and pharmacokinetics of the orally available antiprionic compound PRI-002: A single and multiple ascending dose phase I study
    Kutzsche, Janine
    Jurgens, Dagmar
    Willuweit, Antje
    Adermann, Knut
    Fuchs, Carola
    Simons, Stefanie
    Windisch, Manfred
    Humpel, Michael
    Rossberg, Wolfgang
    Wolzt, Michael
    Willbold, Dieter
    ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS, 2020, 6 (01)
  • [40] Phase I ascending single and multiple dose studies to assess the safety, tolerability and pharmacokinetics of AZD0530, a highly selective, dual-specific Src-Abl inhibitor
    Lockton, JA
    Smethurst, D
    Macpherson, M
    Tootell, R
    Marshall, AL
    Clack, G
    Gallagher, NJ
    JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (16) : 223S - 223S