ATPase binding and consequent disassembly of the type VI secretion system in Vibrio cholerae: a dynamic model

被引：0
|
作者：
Smith-Roberge, Julien [1 ]
Stietz, Maria Silvina [2 ]
Dong, Tao G. [2 ]
Ingalls, Brian [1 ]
机构：
[1] Univ Waterloo, Dept Appl Math, Waterloo, ON, Canada
[2] Univ Calgary, Dept Ecosyst & Publ Hlth, Calgary, AB, Canada
来源：
IFAC PAPERSONLINE | 2018年 / 51卷 / 19期
关键词：
Stochastic modelling; Mathematical models; type VI secretion system;
D O I：
10.1016/j.ifacol.2018.09.035
中图分类号：
TP [自动化技术、计算机技术];
学科分类号：
0812 ;
摘要：
The type VI secretion system, an organelle common to Gram-negative bacteria, is disassembled in a process mediated by the binding of ClpV ATPase. Fluorescence microscopy experiments in Vibrio cholerae have revealed that, during the course of this disassembly, the organelle breaks into pieces which appear to contract. We developed and analysed a dynamic model of ClpV binding. Our findings suggest that this breaking behavior is not directly triggered by accumulated ClpV binding. (C) 2018, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.
引用
收藏
页码：82 / 83
页数：2
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