Comparison of the postoperative analgesic effects of naproxen sodium and naproxen sodium-codeine phosphate for arthroscopic meniscus surgery

被引:1
|
作者
Bali, Cagla [1 ]
Ergenoglu, Pinar [1 ]
Ozmete, Ozlem [1 ]
Akin, Sule [1 ]
Ozyilkan, Nesrin Bozdogan [1 ]
Cok, Oya Yalcin [1 ]
Aribogan, Anis [1 ]
机构
[1] Baskent Univ, Sch Med, Dept Anestesiol & Reanim, Adana, Turkey
来源
REVISTA BRASILEIRA DE ANESTESIOLOGIA | 2016年 / 66卷 / 02期
关键词
Arthroscopy; Postoperative analgesia; Naproxen sodium; Codeine phosphate; INTRAMUSCULAR KETOROLAC; MORPHINE-SULFATE; ORAL NAPROXEN; KNEE SURGERY; PAIN; TROMETHAMINE; COMBINATION; EFFICACY;
D O I
10.1016/j.bjan.2016.01.005
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background and objectives: Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used to control arthroscopic pain. Addition of oral effective opioid "codeine" to NSAIDs may be more effective and decrease parenteral opioid consumption in the postoperative period. The aim of this study was to compare the efficacy and side effects of naproxen sodium and a new preparation naproxen sodium-codeine phosphate when administered preemptively for arthroscopic meniscectomy. Methods: Sixty-one patients were randomized into two groups to receive either oral naproxen sodium (Group N) or naproxen sodium-codeine phosphate (Group NC) before surgery. The surgery was carried out under general anesthesia. Intravenous meperidine was initiated by patient-controlled analgesia (PCA) for all patients. The primary outcome measure was pain score at the first postoperative hour assessed by the Visual Analogue Scale (VAS). Sedation assessed by Ramsey Sedation Scale, first demand time of PCA, postoperative meperidine consumption, side effects and hemodynamic data were also recorded. Results: The groups were demographically comparable. Median VAS scores both at rest and on movement were significantly lower in Group NC compared with Group N. except 18th hour on movement (p < 0.05). The median time to the first demand of PCA was shorter in Group N compared with Group NC (p < 0.001). Meperidine consumption was higher in Group N compared with Group NC (p < 0.001). There was no difference between groups with respect to side effects (p > 0.05). Conclusions: The combination of naproxen sodium-codeine phosphate provided more effective analgesia than naproxen sodium and did not increase side effects. (C) 2014 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.
引用
收藏
页码:151 / 156
页数:6
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