Comparison of the postoperative analgesic effects of paracetamol-codeine phosphate and naproxen sodium-codeine phosphate for lumbar disk surgery

被引:5
|
作者
Polat, Reyhan [1 ]
Peker, Kevser [1 ]
Guloksuz, Cigdem Topcu [2 ]
Ergil, Julide [1 ]
Akkaya, Taylan [1 ]
机构
[1] Diskapi Yildirim Beyazit Res & Training Hosp, Dept Anesthesiol, Minist Hlth, Ankara, Turkey
[2] Bartin Univ, Fac Sci, Dept Stat, Bartin, Turkey
来源
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES | 2015年 / 31卷 / 09期
关键词
Analgesics; Lumbar disk surgery; Naproxen sodium; Nonnarcotic analgesics; Paracetamol; PATIENT-CONTROLLED ANALGESIA; INTRAVENOUS PARACETAMOL; ANTIINFLAMMATORY DRUGS; CONTROLLED-TRIALS; ORAL NAPROXEN; PAIN; MORPHINE; KETOPROFEN; EFFICACY; ACETAMINOPHEN;
D O I
10.1016/j.kjms.2015.07.001
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The aim of this study was to compared the efficacy of paracetamol-codeine phosphate and naproxen sodium-codeine phosphate on postoperative pain and tramadol consumption during the first 24 hours after a lumbar disk surgery. After Ethics Committee approval and informed consent had been obtained, 64 patients were allocated into three groups. Patients received oral paracetamol-codeine (300 mg + 30 mg; Group P), naproxen sodium-codeine (550 mg + 30 mg; Group N), or placebo tablets (Group C) 30 minutes prior to induction of anesthesia. Patient-controlled analgesia was supplied postoperatively using tramadol. Pain intensity, tramadol consumption, and side effects were recorded every 1 hour, 2 hours, 6 hours, 12 hours, and 24 hours after surgery. Whole study period pain intensity (visual analogue scale scores) was lower in Group P (p = 0.007) and Group N (p = 0.001), compared with Group C, however, there was no statistically significant difference between Group P and Group N regarding pain intensity (p > 0.05). Tramadol consumption was lower in Group P and Group N, compared with Group C (p < 0.001), and in turn the lowest incidence of tramadol consumption was detected in Group P compared with Group N (p < 0.001) and Group C (p < 0.001). Side effects were similar between the groups. Preemptive administration of paracetamol-codeine and naproxen sodium-codeine combination significantly reduced tramadol consumption and provided more effective analgesia compared with placebo. The paracetamol-codeine combination was superior to naproxen sodium-codeine with regard to tramadol consumption. Copyright (C) 2015, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.
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页码:468 / 472
页数:5
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