Quantitative Computed Tomography Parameters in Coronavirus Disease 2019 Patients and Prediction of Respiratory Outcomes Using a Decision Tree

被引:2
|
作者
Kang, Jieun [1 ]
Kang, Jiyeon [1 ]
Seo, Woo Jung [1 ]
Park, So Hee [1 ]
Kang, Hyung Koo [1 ]
Park, Hye Kyeong [1 ]
Song, Je Eun [2 ]
Kwak, Yee Gyung [2 ]
Chang, Jeonghyun [3 ]
Kim, Sollip [3 ]
Kim, Ki Hwan [4 ]
Park, Junseok [5 ]
Choe, Won Joo [6 ]
Lee, Sung-Soon [1 ]
Koo, Hyeon-Kyoung [1 ]
机构
[1] Inje Univ, Ilsan Paik Hosp, Coll Med, Dept Internal Med,Div Pulm & Crit Care Med, Goyang, South Korea
[2] Inje Univ, Ilsan Paik Hosp, Coll Med, Dept Internal Med,Div Infect Dis, Goyang, South Korea
[3] Inje Univ, Ilsan Paik Hosp, Coll Med, Dept Lab Med, Goyang, South Korea
[4] Inje Univ, Ilsan Paik Hosp, Coll Med, Dept Radiol, Goyang, South Korea
[5] Inje Univ, Ilsan Paik Hosp, Coll Med, Dept Emergency Med, Goyang, South Korea
[6] Inje Univ, Ilsan Paik Hosp, Coll Med, Dept Anesthesiol & Pain Med, Goyang, South Korea
关键词
coronavirus disease 2019; pneumonia; hypoxia; respiratory failure; quantitative CT; decision tree; COVID-19; CT; PROGRESSION; DIMENSIONS; PNEUMONIA; SEVERITY;
D O I
10.3389/fmed.2022.914098
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BackgroundChest computed tomography (CT) scans play an important role in the diagnosis of coronavirus disease 2019 (COVID-19). This study aimed to describe the quantitative CT parameters in COVID-19 patients according to disease severity and build decision trees for predicting respiratory outcomes using the quantitative CT parameters. MethodsPatients hospitalized for COVID-19 were classified based on the level of disease severity: (1) no pneumonia or hypoxia, (2) pneumonia without hypoxia, (3) hypoxia without respiratory failure, and (4) respiratory failure. High attenuation area (HAA) was defined as the quantified percentage of imaged lung volume with attenuation values between -600 and -250 Hounsfield units (HU). Decision tree models were built with clinical variables and initial laboratory values (model 1) and including quantitative CT parameters in addition to them (model 2). ResultsA total of 387 patients were analyzed. The mean age was 57.8 years, and 50.3% were women. HAA increased as the severity of respiratory outcome increased. HAA showed a moderate correlation with lactate dehydrogenases (LDH) and C-reactive protein (CRP). In the decision tree of model 1, the CRP, fibrinogen, LDH, and gene Ct value were chosen as classifiers whereas LDH, HAA, fibrinogen, vaccination status, and neutrophil (%) were chosen in model 2. For predicting respiratory failure, the decision tree built with quantitative CT parameters showed a greater accuracy than the model without CT parameters. ConclusionsThe decision tree could provide higher accuracy for predicting respiratory failure when quantitative CT parameters were considered in addition to clinical characteristics, PCR Ct value, and blood biomarkers.
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页数:9
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