Self-assembled amphoterecin B loaded into a self-assembled cardanol derivative as a soft green carrier for delivery and enhanced antifungal activity

被引：3
|
作者：
Mahata, Denial [1 ]
Mandal, Santi M. [1 ,2 ]
Nando, Golok B. [1 ]
机构：
[1] Indian Inst Technol, Cent Res Facil, Ctr Rubber Technol, Kharagpur 721302, W Bengal, India
[2] Vidyasagar Univ, Dept Microbiol, Midnapore 721102, WB, India
来源：
RSC ADVANCES | 2014年 / 4卷 / 89期
关键词：
TOXICITY; EPIDEMIOLOGY; THERAPY; BINDING; CNSL;
D O I：
10.1039/c4ra07617f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Self-assembly strategies are used for soft green carrier (SGC) preparation from cardanol after modification with benzenediazonium functional moieties (PHPDB). A spherical core-shell like self-assembled structure of Amphotericin B (AmpB) was loaded into PHPDB and released in aqueous medium. AmpB and PHPDB show ergosterol and chitin binding affinity, respectively, and sustain enhanced activity with proficient biofilm eradication.
引用
收藏
页码：48559 / 48562
页数：4
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