Synthesis and Class III type antiarrhythmic activity of 4-aroyl (and aryl)-1-aralkylpiperazines

被引：5
|
作者：
Kanojia, RM [1 ]
Salata, JJ [1 ]
Kauffman, J [1 ]
机构：
[1] RW Johnson Pharmaceut Res Inst, Raritan, NJ 08869 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 24期
关键词：
D O I：
10.1016/S0960-894X(00)00581-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis and in vitro Class III antiarrhythmic activity of several 4-aroyl (and aryl)-1-aralkylpiperazine and piperidine derivatives are described. Among several potent compounds identified in the series, RWJ-28810 (3), with its EC50 of 3 nM, ranks as one of the most potent (in vitro) compounds reported. (C) 2000 Elsevier Science Ltd. All rights reserved.
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收藏
页码：2819 / 2823
页数：5
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