A supramolecular sensor array for selective immunoglobulin deficiency analysis

被引：10
|
作者：
Liu, Yang [1 ]
Gill, Adam D. [2 ]
Duan, Yaokai [3 ]
Perez, Lizeth [3 ]
Hooley, Richard J. [2 ,3 ]
Zhong, Wenwan [1 ,3 ]
机构：
[1] Univ Calif Riverside, Environm Toxicol Program, Riverside, CA 92521 USA
[2] Univ Calif Riverside, Dept Biochem & Mol Biol, Riverside, CA 92521 USA
[3] Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 77期
基金：
美国国家科学基金会;
关键词：
PROTEIN; NANOPARTICLES; ASSAY;
D O I：
10.1039/c9cc06064b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A host-guest based fluorescence sensor array can sense small differences in protein structure. The combination of three cavitand hosts and two fluorophores to form a 4-component array is sufficient to fully discriminate five structurally similar Ig protein isotypes. The array can be applied to recognize Ig deficiencies in serum, when combined with a Protein L-based extraction process, allowing analysis of immunodeficiency in a simpler, lower cost manner than tests that require multiple specific antibodies.
引用
收藏
页码：11563 / 11566
页数：4
相关论文
共 50 条
  • [41] Selective immunoglobulin A deficiency is exceptionally associated with multiple sclerosis
    Pereira, L. F.
    Gomez, M.
    Garcia Trujillo, J. A.
    Romero Chala, S.
    Camara Hijon, C.
    NEUROLOGIA, 2012, 27 (05): : 316 - 316
  • [42] Hay-wells syndrome with selective immunoglobulin a deficiency
    Sharanya, Bhupathi
    Narayanan, Rajendran
    Karunanandhan, Manobalan
    INDIAN JOURNAL OF PAEDIATRIC DERMATOLOGY, 2020, 21 (04) : 307 - 309
  • [43] Selective Immunoglobulin M Deficiency in a Patient With Refractory Giardiasis
    Kampitak, T.
    JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY, 2010, 20 (04) : 358 - 360
  • [44] HYPOGAMMAGLOBULINEMIA AND SELECTIVE IMMUNOGLOBULIN A DEFICIENCY - DOUBLE CONSANGUINITY IN FAMILY
    ROSNER, F
    VALLEJO, V
    KHAN, FA
    WESSELY, Z
    GRUNWALD, HW
    CALAS, C
    NEW YORK STATE JOURNAL OF MEDICINE, 1978, 78 (09) : 1459 - 1463
  • [45] A case of selective immunoglobulin M deficiency and autoimmune glomerulonephritis
    Antar, Marina
    Lamarche, Jorge
    Peguero, Alfredo
    Reiss, Alexander
    Cole, Steven
    CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2008, 12 (04) : 300 - 304
  • [46] SELECTIVE IMMUNOGLOBULIN A DEFICIENCY IN 2 PATIENTS WITH ALCOHOLIC CIRRHOSIS
    WILSON, ID
    ONSTAD, GR
    WILLIAMS, RC
    CAREY, JB
    GASTROENTEROLOGY, 1968, 54 (02) : 253 - &
  • [47] SELECTIVE IMMUNOGLOBULIN A DEFICIENCY ASSOCIATED WITH NODULAR LYMPHOID HYPERPLASIA
    JACOBSON, KW
    DESHAZO, RD
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1979, 64 (06) : 516 - 521
  • [48] Helicobacter pylori infection in patients with selective immunoglobulin a deficiency
    Magen, E.
    Waitman, D. -A.
    Goldstein, N.
    Schlesinger, M.
    Dickstein, Y.
    Kahan, N. R.
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2016, 184 (03): : 332 - 337
  • [49] Selective immunoglobulin m deficiency in a patient with recurrent sinusitis
    de Vera, M
    Tobin, MC
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2000, 105 (01) : S224 - S225
  • [50] Calixarene-Based Supramolecular Sensor Array for Pesticide Discrimination
    Chen, Yeye
    Tian, Jia-Hong
    Tian, Han-Wen
    Ma, Rong
    Wang, Ze-Han
    Pan, Yu-Chen
    Hu, Xin-Yue
    Guo, Dong-Sheng
    SENSORS, 2024, 24 (12)
12345