A supramolecular sensor array for selective immunoglobulin deficiency analysis

被引：10
|
作者：
Liu, Yang [1 ]
Gill, Adam D. [2 ]
Duan, Yaokai [3 ]
Perez, Lizeth [3 ]
Hooley, Richard J. [2 ,3 ]
Zhong, Wenwan [1 ,3 ]
机构：
[1] Univ Calif Riverside, Environm Toxicol Program, Riverside, CA 92521 USA
[2] Univ Calif Riverside, Dept Biochem & Mol Biol, Riverside, CA 92521 USA
[3] Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 77期
基金：
美国国家科学基金会;
关键词：
PROTEIN; NANOPARTICLES; ASSAY;
D O I：
10.1039/c9cc06064b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A host-guest based fluorescence sensor array can sense small differences in protein structure. The combination of three cavitand hosts and two fluorophores to form a 4-component array is sufficient to fully discriminate five structurally similar Ig protein isotypes. The array can be applied to recognize Ig deficiencies in serum, when combined with a Protein L-based extraction process, allowing analysis of immunodeficiency in a simpler, lower cost manner than tests that require multiple specific antibodies.
引用
收藏
页码：11563 / 11566
页数：4
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